Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

P. F. Koh; P. Wang; J. M. Huang; T. P. Loh

doi:10.1039/c4cc02645d

Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

P. F. Koh, P. Wang, J. M. Huang, T. P. Loh

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK₁ receptor antagonist.

Original language	English
Pages (from-to)	8324-8327
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	61
DOIs	https://doi.org/10.1039/c4cc02645d
State	Published - 3 Jul 2014
Externally published	Yes

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abstract = "An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.",

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AU - Wang, P.

AU - Huang, J. M.

AU - Loh, T. P.

PY - 2014/7/3

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AB - An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.

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Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

Abstract

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