Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives

Yin Lin Qin; Lei Chen; Wei He; Mei Su; Qiu Jin; Zheng Fang; Ping Kai Ouyang; Kai Guo

doi:10.1080/10286020.2017.1337751

Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives

Yin Lin Qin, Lei Chen, Wei He, Mei Su, Qiu Jin, Zheng Fang, Ping Kai Ouyang, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.

Original language	English
Pages (from-to)	139-147
Number of pages	9
Journal	Journal of Asian Natural Products Research
Volume	20
Issue number	2
DOIs	https://doi.org/10.1080/10286020.2017.1337751
State	Published - 1 Feb 2018

Keywords

Tanshinone IIA
amidation
anti-myocardial injury
slat-forming
sulfonation

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10.1080/10286020.2017.1337751

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title = "Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives",

abstract = "A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.",

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AU - Qin, Yin Lin

AU - Chen, Lei

AU - He, Wei

AU - Su, Mei

AU - Jin, Qiu

AU - Fang, Zheng

AU - Ouyang, Ping Kai

AU - Guo, Kai

PY - 2018/2/1

Y1 - 2018/2/1

N2 - A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.

AB - A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46 μM) activity compared with esmolol (8.12 μM). In addition, they also displayed a concentration-dependent inhibition on the anti-myocardial injury.

KW - Tanshinone IIA

KW - amidation

KW - anti-myocardial injury

KW - slat-forming

KW - sulfonation

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AN - SCOPUS:85020683595

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EP - 147

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 2

ER -

Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives

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Keywords

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