Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Wenbo Hu; Hengheng Ma; Bing Hou; Hui Zhao; Yu Ji; Rongcui Jiang; Xiaoming Hu; Xiaomei Lu; Lei Zhang; Yufu Tang; Quli Fan; Wei Huang

doi:10.1021/acsami.6b02721

Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Wenbo Hu, Hengheng Ma, Bing Hou, Hui Zhao, Yu Ji, Rongcui Jiang, Xiaoming Hu, Xiaomei Lu, Lei Zhang, Yufu Tang, Quli Fan, Wei Huang

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

Original language	English
Pages (from-to)	12039-12047
Number of pages	9
Journal	ACS Applied Materials and Interfaces
Volume	8
Issue number	19
DOIs	https://doi.org/10.1021/acsami.6b02721
State	Published - 18 May 2016

Keywords

lysosome-targeting
near-infrared absorption
photoacoustic imaging
photodynamic therapy
theranostic nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.6b02721

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title = "Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light",

abstract = "Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.",

keywords = "lysosome-targeting, near-infrared absorption, photoacoustic imaging, photodynamic therapy, theranostic nanoparticles",

author = "Wenbo Hu and Hengheng Ma and Bing Hou and Hui Zhao and Yu Ji and Rongcui Jiang and Xiaoming Hu and Xiaomei Lu and Lei Zhang and Yufu Tang and Quli Fan and Wei Huang",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = may,

day = "18",

doi = "10.1021/acsami.6b02721",

language = "英语",

volume = "8",

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T1 - Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

AU - Hu, Wenbo

AU - Ma, Hengheng

AU - Hou, Bing

AU - Zhao, Hui

AU - Ji, Yu

AU - Jiang, Rongcui

AU - Hu, Xiaoming

AU - Lu, Xiaomei

AU - Zhang, Lei

AU - Tang, Yufu

AU - Fan, Quli

AU - Huang, Wei

PY - 2016/5/18

Y1 - 2016/5/18

N2 - Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

AB - Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

KW - lysosome-targeting

KW - near-infrared absorption

KW - photoacoustic imaging

KW - photodynamic therapy

KW - theranostic nanoparticles

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U2 - 10.1021/acsami.6b02721

DO - 10.1021/acsami.6b02721

M3 - 文章

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AN - SCOPUS:84971264957

SN - 1944-8244

VL - 8

SP - 12039

EP - 12047

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 19

ER -

Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Abstract

Keywords

UN SDGs

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