Iron-catalyzed cascade carbochloromethylation of activated alkenes: Highly efficient access to chloro-containing oxindoles

Ming Zhu Lu; Teck Peng Loh

doi:10.1021/ol502411c

Iron-catalyzed cascade carbochloromethylation of activated alkenes: Highly efficient access to chloro-containing oxindoles

Ming Zhu Lu, Teck Peng Loh

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137 Scopus citations

Abstract

An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.

Original language	English
Pages (from-to)	4698-4701
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	18
DOIs	https://doi.org/10.1021/ol502411c
State	Published - 19 Sep 2014
Externally published	Yes

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title = "Iron-catalyzed cascade carbochloromethylation of activated alkenes: Highly efficient access to chloro-containing oxindoles",

abstract = "An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.",

author = "Lu, {Ming Zhu} and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",

year = "2014",

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doi = "10.1021/ol502411c",

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T2 - Highly efficient access to chloro-containing oxindoles

AU - Lu, Ming Zhu

AU - Loh, Teck Peng

PY - 2014/9/19

Y1 - 2014/9/19

N2 - An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.

AB - An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.

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U2 - 10.1021/ol502411c

DO - 10.1021/ol502411c

M3 - 文章

C2 - 25203302

AN - SCOPUS:84908628951

SN - 1523-7060

VL - 16

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EP - 4701

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Iron-catalyzed cascade carbochloromethylation of activated alkenes: Highly efficient access to chloro-containing oxindoles

Abstract

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