Nanoscale-controlled enzymatic degradation of poly(L -lactic acid) films using dip-pen nanolithography

Hai Li; Qiyuan He; Xiaohong Wang; Gang Lu; Cipto Liusman; Bing Li; Freddy Boey; Subbu S. Venkatraman; Hua Zhang

doi:10.1002/smll.201001977

Nanoscale-controlled enzymatic degradation of poly(L -lactic acid) films using dip-pen nanolithography

Hai Li, Qiyuan He, Xiaohong Wang, Gang Lu, Cipto Liusman, Bing Li, Freddy Boey, Subbu S. Venkatraman, Hua Zhang

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.

Original language	English
Pages (from-to)	226-229
Number of pages	4
Journal	Small
Volume	7
Issue number	2
DOIs	https://doi.org/10.1002/smll.201001977
State	Published - 17 Jan 2011
Externally published	Yes

Keywords

biodegradation
biological activity
dip-pen nanolithography
enzymes
patterning

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10.1002/smll.201001977

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title = "Nanoscale-controlled enzymatic degradation of poly(L -lactic acid) films using dip-pen nanolithography",

abstract = "Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.",

keywords = "biodegradation, biological activity, dip-pen nanolithography, enzymes, patterning",

author = "Hai Li and Qiyuan He and Xiaohong Wang and Gang Lu and Cipto Liusman and Bing Li and Freddy Boey and Venkatraman, {Subbu S.} and Hua Zhang",

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doi = "10.1002/smll.201001977",

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T1 - Nanoscale-controlled enzymatic degradation of poly(L -lactic acid) films using dip-pen nanolithography

AU - Li, Hai

AU - He, Qiyuan

AU - Wang, Xiaohong

AU - Lu, Gang

AU - Liusman, Cipto

AU - Li, Bing

AU - Boey, Freddy

AU - Venkatraman, Subbu S.

AU - Zhang, Hua

PY - 2011/1/17

Y1 - 2011/1/17

N2 - Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.

AB - Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.

KW - biodegradation

KW - biological activity

KW - dip-pen nanolithography

KW - enzymes

KW - patterning

UR - http://www.scopus.com/inward/record.url?scp=78651293097&partnerID=8YFLogxK

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DO - 10.1002/smll.201001977

M3 - 文章

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AN - SCOPUS:78651293097

SN - 1613-6810

VL - 7

SP - 226

EP - 229

JO - Small

JF - Small

IS - 2

ER -

Nanoscale-controlled enzymatic degradation of poly(L -lactic acid) films using dip-pen nanolithography

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Keywords

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