Research on metastable zone of adenosine 5'-monophosphate in ethanol and water

Jun Ma; Jun Shi; Lei Zhang; Hao Lu; Han Jie Ying

Research on metastable zone of adenosine 5'-monophosphate in ethanol and water

Jun Ma, Jun Shi, Lei Zhang, Hao Lu, Han Jie Ying

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

Abstract

Qualitative data on the solubility and supersolubility for binary system 5'-AMP + H₂O solution and ternary system 5'-AMP + H₂O + ethanol solution was determined at 293-323 K in the volume fraction ethanol range of 0.3-2.0, which were essential for solvent-out crystallization studies. The supersolubility of 5'-AMP fulfills well the empirical formula in both pure water and H₂O + ethanol solution. Temperature, ethanol addition rate, pH levels and rotate speed of stirrer were being recognized as nonvasive control parameter for adenosine 5'-monophosphate crystallization. The metastable zone was obtained under the conditions of temperatures, ethanol addition rate, pH levels and rotate speed of stirrer and estimated by using Central Composite Designs in the solvent-out crystallization process, and the variation of crystal habit of 5'-AMP was studied by scanning electron microscope after optimization of the crystallization process. All the results were important for the control of industrial crystallization of 5'-AMP.

Original language	English
Pages (from-to)	16-19
Number of pages	4
Journal	Huaxue Gongcheng/Chemical Engineering (China)
Volume	35
Issue number	10
State	Published - Oct 2007

Keywords

5'-AMP
Crystallization
Metastable zone
Solubility
Supersolubility

Cite this

@article{cb9159f9916f425594eca16e07ec349e,

title = "Research on metastable zone of adenosine 5'-monophosphate in ethanol and water",

abstract = "Qualitative data on the solubility and supersolubility for binary system 5'-AMP + H2O solution and ternary system 5'-AMP + H2O + ethanol solution was determined at 293-323 K in the volume fraction ethanol range of 0.3-2.0, which were essential for solvent-out crystallization studies. The supersolubility of 5'-AMP fulfills well the empirical formula in both pure water and H2O + ethanol solution. Temperature, ethanol addition rate, pH levels and rotate speed of stirrer were being recognized as nonvasive control parameter for adenosine 5'-monophosphate crystallization. The metastable zone was obtained under the conditions of temperatures, ethanol addition rate, pH levels and rotate speed of stirrer and estimated by using Central Composite Designs in the solvent-out crystallization process, and the variation of crystal habit of 5'-AMP was studied by scanning electron microscope after optimization of the crystallization process. All the results were important for the control of industrial crystallization of 5'-AMP.",

keywords = "5'-AMP, Crystallization, Metastable zone, Solubility, Supersolubility",

author = "Jun Ma and Jun Shi and Lei Zhang and Hao Lu and Ying, {Han Jie}",

year = "2007",

month = oct,

language = "英语",

volume = "35",

pages = "16--19",

journal = "Huaxue Gongcheng/Chemical Engineering (China)",

issn = "1005-9954",

publisher = "Editorial Office of Chemical Engineering (China)",

number = "10",

}

TY - JOUR

T1 - Research on metastable zone of adenosine 5'-monophosphate in ethanol and water

AU - Ma, Jun

AU - Shi, Jun

AU - Zhang, Lei

AU - Lu, Hao

AU - Ying, Han Jie

PY - 2007/10

Y1 - 2007/10

N2 - Qualitative data on the solubility and supersolubility for binary system 5'-AMP + H2O solution and ternary system 5'-AMP + H2O + ethanol solution was determined at 293-323 K in the volume fraction ethanol range of 0.3-2.0, which were essential for solvent-out crystallization studies. The supersolubility of 5'-AMP fulfills well the empirical formula in both pure water and H2O + ethanol solution. Temperature, ethanol addition rate, pH levels and rotate speed of stirrer were being recognized as nonvasive control parameter for adenosine 5'-monophosphate crystallization. The metastable zone was obtained under the conditions of temperatures, ethanol addition rate, pH levels and rotate speed of stirrer and estimated by using Central Composite Designs in the solvent-out crystallization process, and the variation of crystal habit of 5'-AMP was studied by scanning electron microscope after optimization of the crystallization process. All the results were important for the control of industrial crystallization of 5'-AMP.

AB - Qualitative data on the solubility and supersolubility for binary system 5'-AMP + H2O solution and ternary system 5'-AMP + H2O + ethanol solution was determined at 293-323 K in the volume fraction ethanol range of 0.3-2.0, which were essential for solvent-out crystallization studies. The supersolubility of 5'-AMP fulfills well the empirical formula in both pure water and H2O + ethanol solution. Temperature, ethanol addition rate, pH levels and rotate speed of stirrer were being recognized as nonvasive control parameter for adenosine 5'-monophosphate crystallization. The metastable zone was obtained under the conditions of temperatures, ethanol addition rate, pH levels and rotate speed of stirrer and estimated by using Central Composite Designs in the solvent-out crystallization process, and the variation of crystal habit of 5'-AMP was studied by scanning electron microscope after optimization of the crystallization process. All the results were important for the control of industrial crystallization of 5'-AMP.

KW - 5'-AMP

KW - Crystallization

KW - Metastable zone

KW - Solubility

KW - Supersolubility

UR - http://www.scopus.com/inward/record.url?scp=36249007954&partnerID=8YFLogxK

M3 - 文章

AN - SCOPUS:36249007954

SN - 1005-9954

VL - 35

SP - 16

EP - 19

JO - Huaxue Gongcheng/Chemical Engineering (China)

JF - Huaxue Gongcheng/Chemical Engineering (China)

IS - 10

ER -

Research on metastable zone of adenosine 5'-monophosphate in ethanol and water

Abstract

Keywords

Other files and links

Fingerprint

Cite this