Viral mimicking ternary polyplexes: A reduction-controlled hierarchical unpacking vector for gene delivery

Yiyan He; Yu Nie; Gang Cheng; Li Xie; Youqing Shen; Zhongwei Gu

doi:10.1002/adma.201304592

Viral mimicking ternary polyplexes: A reduction-controlled hierarchical unpacking vector for gene delivery

Yiyan He, Yu Nie, Gang Cheng, Li Xie, Youqing Shen, Zhongwei Gu

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Reduction-controlled hierarchical unpacking is proposed for the development of virus-mimicking gene carriers. Disulfide-bond-modified hyaluronic acid (HA) is deposited onto the surface of diselenide-conjugated oligoethylenimine/DNA polyplexes to form DNA/OEI-SeSe_x/HA-SS-COOH (DOS) polyplexes. The cleavage of the disulfide and diselenide bonds is triggered by the gradient GSH level at the tumor site and inside the cells. The transfection efficiency of DOS show significant enhancement over DNA/poly(ethylene imine) (DP) in vitro and in vivo.

Original language	English
Pages (from-to)	1534-1540
Number of pages	7
Journal	Advanced Materials
Volume	26
Issue number	10
DOIs	https://doi.org/10.1002/adma.201304592
State	Published - 12 Mar 2014
Externally published	Yes

Keywords

gene delivery
hierarchical unpacking
hyaluronic acid
oligoethyleneimine
polyplexes
reduction control

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10.1002/adma.201304592

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abstract = "Reduction-controlled hierarchical unpacking is proposed for the development of virus-mimicking gene carriers. Disulfide-bond-modified hyaluronic acid (HA) is deposited onto the surface of diselenide-conjugated oligoethylenimine/DNA polyplexes to form DNA/OEI-SeSex/HA-SS-COOH (DOS) polyplexes. The cleavage of the disulfide and diselenide bonds is triggered by the gradient GSH level at the tumor site and inside the cells. The transfection efficiency of DOS show significant enhancement over DNA/poly(ethylene imine) (DP) in vitro and in vivo.",

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T2 - A reduction-controlled hierarchical unpacking vector for gene delivery

AU - He, Yiyan

AU - Nie, Yu

AU - Cheng, Gang

AU - Xie, Li

AU - Shen, Youqing

AU - Gu, Zhongwei

PY - 2014/3/12

Y1 - 2014/3/12

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AB - Reduction-controlled hierarchical unpacking is proposed for the development of virus-mimicking gene carriers. Disulfide-bond-modified hyaluronic acid (HA) is deposited onto the surface of diselenide-conjugated oligoethylenimine/DNA polyplexes to form DNA/OEI-SeSex/HA-SS-COOH (DOS) polyplexes. The cleavage of the disulfide and diselenide bonds is triggered by the gradient GSH level at the tumor site and inside the cells. The transfection efficiency of DOS show significant enhancement over DNA/poly(ethylene imine) (DP) in vitro and in vivo.

KW - gene delivery

KW - hierarchical unpacking

KW - hyaluronic acid

KW - oligoethyleneimine

KW - polyplexes

KW - reduction control

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Viral mimicking ternary polyplexes: A reduction-controlled hierarchical unpacking vector for gene delivery

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Keywords

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