重组贻贝足蛋白的研究进展与应用

Mussel foot proteins are a kind of protein complex secreted by mussel foot gland, which have strong adhesion to the surface of substrates due to reactions. Because of its strong adhesion, biodegradability and excellent biocompatibility in the marine environments, it is often used as bio-medical adhesives. However, the extraction of natural proteins is limited by the source of raw materials, and the complex process leads to high price, which hinders the further application and development of mussel foot proteins. The latest development of microbial synthesis provides a new way of thinking for mussel foot protein production and has the significance of expanding the scale of production. The production methods of mussel foot protein by genetic engineering were reviewed, and the applications of recombinant proteins in adhesion antifouling coatings and tissue engineering materials were summarized. At the same time, the research direction is prospected, and it is pointed out that the key technology for the further development of recombinant mussel foot proteins is to analyze the structure activity and hierarchical structure of the protein, on the basis of which the expression level of the protein is improved, so as to obtain more derivatives with biological efficacy.