基于金刚烷-二氧杂环丁烷化学发光探针的研究进展

Chemiluminescence is released by its chemical reaction instead of light energy excitation to generate optical signals, which has the advantages of low background, no autofluorescence interference and high sensitivity. In recent years, chemiluminescence imaging technology, especially dioxetane chemiluminescence probe in biological imaging, has been developed rapidly. Glow-type adamantane-dioxetane chemiluminescence have been widely used for ion detection (fluoride ions), specific identification of bioactive species (reactive oxygen species, active sulfur species), biomarker enzymes (β-galactosidase, nitroreductase, cathepsin B, etc.) and the development of chemiluminescence materials. This article summarizes the research progress of adamantane-dioxetane chemiluminescence in the above four aspects in recent years, and prospects the research direction in this field.