3D Printed Biocatalytic Living Materials with Dual-Network Reinforced Bioinks

Fukun He, Yangteng Ou, Ji Liu, Qiu Huang, Bao Tang, Fengxue Xin, Jing Zhang, Min Jiang, Su Chen, Ziyi Yu

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The field of living materials seeks to harness living cells as microfactories that can construct a material itself or enhance the performance of material in some manner. While recent advances in 3D printing allow microbe manipulation to create bespoke living materials, the effective coupling of these living components in reinforced bioink designs remains a major challenge due to the difficulty in building a robust and cell-friendly microenvironment. Here, a type of dual-network bioink is reported for the 3D printing of living materials with enhanced biocatalysis capabilities, where bioinks are readily printable and provide a biocompatible environment along with desirable mechanical performance. It is demonstrated that integrating microbes into these bioinks enables the direct printing of catalytically living materials with high cell viability and maintains metabolic activity, which those living materials can be preserved and reused. Further, a bacteria-algae coculture system is fabricated for the bioremediation of chemicals, giving rise to its potential field applications.

Original languageEnglish
Article number2104820
JournalSmall
Volume18
Issue number6
DOIs
StatePublished - 10 Feb 2022

Keywords

  • 3D printing
  • bioinks
  • dual-network
  • living materials

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