A double-network polysaccharide-based composite hydrogel for skin wound healing

Yuxin He; Yang Li; Yadong Sun; Shijia Zhao; Miao Feng; Guoming Xu; Haofang Zhu; Peihong Ji; Hongli Mao; Yiyan He; Zhongwei Gu

doi:10.1016/j.carbpol.2021.117870

A double-network polysaccharide-based composite hydrogel for skin wound healing

Yuxin He, Yang Li, Yadong Sun, Shijia Zhao, Miao Feng, Guoming Xu, Haofang Zhu, Peihong Ji, Hongli Mao, Yiyan He, Zhongwei Gu

College of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Effective wound dressings are of great significance in preventing infections and promoting wound healing. However, most existing hydrogel dressings have an inadequacy in either mechanical performance, biological activities, or versatilities. Here we presented a double-network cross-linked polysaccharide-based hydrogel composed of collagen peptide-functionalized carboxymethyl chitosan (CS) and oxidized methacrylate sodium alginate (SA). The hydrogel possessed interconnected porous morphologies, suitable swelling ratios, excellent mechanical properties, and favorable biocompatibility. Meanwhile, the in vivo studies using a mouse full-thickness skin defect model showed that the double-network CS/SA hydrogel significantly accelerated wound healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization.

Original language	English
Article number	117870
Journal	Carbohydrate Polymers
Volume	261
DOIs	https://doi.org/10.1016/j.carbpol.2021.117870
State	Published - 1 Jun 2021

Keywords

Carboxymethyl chitosan
Collagen peptide
Double-network hydrogel
Oxidized methacrylate sodium alginate
Wound dressing

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10.1016/j.carbpol.2021.117870

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title = "A double-network polysaccharide-based composite hydrogel for skin wound healing",

abstract = "Effective wound dressings are of great significance in preventing infections and promoting wound healing. However, most existing hydrogel dressings have an inadequacy in either mechanical performance, biological activities, or versatilities. Here we presented a double-network cross-linked polysaccharide-based hydrogel composed of collagen peptide-functionalized carboxymethyl chitosan (CS) and oxidized methacrylate sodium alginate (SA). The hydrogel possessed interconnected porous morphologies, suitable swelling ratios, excellent mechanical properties, and favorable biocompatibility. Meanwhile, the in vivo studies using a mouse full-thickness skin defect model showed that the double-network CS/SA hydrogel significantly accelerated wound healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization.",

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author = "Yuxin He and Yang Li and Yadong Sun and Shijia Zhao and Miao Feng and Guoming Xu and Haofang Zhu and Peihong Ji and Hongli Mao and Yiyan He and Zhongwei Gu",

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T1 - A double-network polysaccharide-based composite hydrogel for skin wound healing

AU - He, Yuxin

AU - Li, Yang

AU - Sun, Yadong

AU - Zhao, Shijia

AU - Feng, Miao

AU - Xu, Guoming

AU - Zhu, Haofang

AU - Ji, Peihong

AU - Mao, Hongli

AU - He, Yiyan

AU - Gu, Zhongwei

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Effective wound dressings are of great significance in preventing infections and promoting wound healing. However, most existing hydrogel dressings have an inadequacy in either mechanical performance, biological activities, or versatilities. Here we presented a double-network cross-linked polysaccharide-based hydrogel composed of collagen peptide-functionalized carboxymethyl chitosan (CS) and oxidized methacrylate sodium alginate (SA). The hydrogel possessed interconnected porous morphologies, suitable swelling ratios, excellent mechanical properties, and favorable biocompatibility. Meanwhile, the in vivo studies using a mouse full-thickness skin defect model showed that the double-network CS/SA hydrogel significantly accelerated wound healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization.

AB - Effective wound dressings are of great significance in preventing infections and promoting wound healing. However, most existing hydrogel dressings have an inadequacy in either mechanical performance, biological activities, or versatilities. Here we presented a double-network cross-linked polysaccharide-based hydrogel composed of collagen peptide-functionalized carboxymethyl chitosan (CS) and oxidized methacrylate sodium alginate (SA). The hydrogel possessed interconnected porous morphologies, suitable swelling ratios, excellent mechanical properties, and favorable biocompatibility. Meanwhile, the in vivo studies using a mouse full-thickness skin defect model showed that the double-network CS/SA hydrogel significantly accelerated wound healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization.

KW - Carboxymethyl chitosan

KW - Collagen peptide

KW - Double-network hydrogel

KW - Oxidized methacrylate sodium alginate

KW - Wound dressing

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U2 - 10.1016/j.carbpol.2021.117870

DO - 10.1016/j.carbpol.2021.117870

M3 - 文章

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AN - SCOPUS:85101753834

SN - 0144-8617

VL - 261

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

M1 - 117870

ER -

A double-network polysaccharide-based composite hydrogel for skin wound healing

Abstract

Keywords

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