A facile synthesis of highly substituted five-membered rings: Mukaiyama-aldol-oxonoium-ene (MAOE) domino reaction

Hao Li; Teck Peng Loh

doi:10.1002/asia.201000884

A facile synthesis of highly substituted five-membered rings: Mukaiyama-aldol-oxonoium-ene (MAOE) domino reaction

Hao Li, Teck Peng Loh

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In the presence of TiBr₄, an efficient and practical method has been developed for the Mukaiyama-aldol-oxonoium-ene reaction of acetals with silyl enol ether. The desired products were obtained in good yields and excellent diastereoselectivities.

Original language	English
Pages (from-to)	1948-1951
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	6
Issue number	8
DOIs	https://doi.org/10.1002/asia.201000884
State	Published - 1 Aug 2011
Externally published	Yes

Keywords

Mukaiyama-aldol reaction
domino reactions
ene reaction
five-membered rings
natural products

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10.1002/asia.201000884

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title = "A facile synthesis of highly substituted five-membered rings: Mukaiyama-aldol-oxonoium-ene (MAOE) domino reaction",

abstract = "In the presence of TiBr4, an efficient and practical method has been developed for the Mukaiyama-aldol-oxonoium-ene reaction of acetals with silyl enol ether. The desired products were obtained in good yields and excellent diastereoselectivities.",

keywords = "Mukaiyama-aldol reaction, domino reactions, ene reaction, five-membered rings, natural products",

author = "Hao Li and Loh, {Teck Peng}",

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AU - Loh, Teck Peng

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AB - In the presence of TiBr4, an efficient and practical method has been developed for the Mukaiyama-aldol-oxonoium-ene reaction of acetals with silyl enol ether. The desired products were obtained in good yields and excellent diastereoselectivities.

KW - Mukaiyama-aldol reaction

KW - domino reactions

KW - ene reaction

KW - five-membered rings

KW - natural products

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A facile synthesis of highly substituted five-membered rings: Mukaiyama-aldol-oxonoium-ene (MAOE) domino reaction

Abstract

Keywords

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