A fluorescent turn-on H2S-responsive probe: Design, synthesis and application

Yufeng Zhang, Haiyan Chen, Dan Chen, Di Wu, Xiaoqiang Chen, Sheng Hua Liu, Jun Yin

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Hydrogen sulfide (H2S) is considered as the third signaling molecule in vivo and it plays an important role in various physiological processes and pathological processes in vivo, such as vasodilation, apoptosis, neurotransmission, ischemia/reperfusion-induced injury, insulin secretion and inflammation. Developing a highly selective and sensitive method that can detect H2S in the biological system is very important. In this work, a colorimetric and "turn-on" fluorescent probe is developed. Furthermore, this probe displays a highly selective response to H2S in aqueous solution and possesses good capability for bioimaging H2S without interference in living cells. The results suggest that a H2S-selective probe has good water-solubility, biocompatibility and cell-penetrability and can serve as an efficient tool for probing H2S in the cell level.

Original languageEnglish
Pages (from-to)9760-9776
Number of pages17
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number38
DOIs
StatePublished - 27 Jul 2015

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