A green resolution-separation process for aliphatic secondary alcohols

Liwei Ren; Tian Xu; Ruoping He; Zhenhua Jiang; Hua Zhou; Ping Wei

doi:10.1016/j.tetasy.2013.01.018

A green resolution-separation process for aliphatic secondary alcohols

Liwei Ren, Tian Xu, Ruoping He, Zhenhua Jiang, Hua Zhou, Ping Wei

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In order to obtain both enantiomers of aliphatic secondary alcohols via a greener method, the four-step resolution-separation process involving lipase-catalyzed enantioselective esterification and hydrolysis as well as two separation procedures both via heterogeneous azeotropic distillation was developed. (S)-2-Pentanol (ee = 98.6%), (R)-2-pentanol (ee >99%), (S)-2-octanol (ee = 98.2%), and (R)-2-octanol (ee = 98.5%) were all produced in high purity (>98%) and high yield (>90%). In addition to the two model substrates, this method could also be applied to the resolution of other aliphatic secondary alcohols.

Original language	English
Pages (from-to)	249-253
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	24
Issue number	5-6
DOIs	https://doi.org/10.1016/j.tetasy.2013.01.018
State	Published - 31 Mar 2013

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title = "A green resolution-separation process for aliphatic secondary alcohols",

abstract = "In order to obtain both enantiomers of aliphatic secondary alcohols via a greener method, the four-step resolution-separation process involving lipase-catalyzed enantioselective esterification and hydrolysis as well as two separation procedures both via heterogeneous azeotropic distillation was developed. (S)-2-Pentanol (ee = 98.6%), (R)-2-pentanol (ee >99%), (S)-2-octanol (ee = 98.2%), and (R)-2-octanol (ee = 98.5%) were all produced in high purity (>98%) and high yield (>90%). In addition to the two model substrates, this method could also be applied to the resolution of other aliphatic secondary alcohols.",

author = "Liwei Ren and Tian Xu and Ruoping He and Zhenhua Jiang and Hua Zhou and Ping Wei",

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T1 - A green resolution-separation process for aliphatic secondary alcohols

AU - Ren, Liwei

AU - Xu, Tian

AU - He, Ruoping

AU - Jiang, Zhenhua

AU - Zhou, Hua

AU - Wei, Ping

PY - 2013/3/31

Y1 - 2013/3/31

N2 - In order to obtain both enantiomers of aliphatic secondary alcohols via a greener method, the four-step resolution-separation process involving lipase-catalyzed enantioselective esterification and hydrolysis as well as two separation procedures both via heterogeneous azeotropic distillation was developed. (S)-2-Pentanol (ee = 98.6%), (R)-2-pentanol (ee >99%), (S)-2-octanol (ee = 98.2%), and (R)-2-octanol (ee = 98.5%) were all produced in high purity (>98%) and high yield (>90%). In addition to the two model substrates, this method could also be applied to the resolution of other aliphatic secondary alcohols.

AB - In order to obtain both enantiomers of aliphatic secondary alcohols via a greener method, the four-step resolution-separation process involving lipase-catalyzed enantioselective esterification and hydrolysis as well as two separation procedures both via heterogeneous azeotropic distillation was developed. (S)-2-Pentanol (ee = 98.6%), (R)-2-pentanol (ee >99%), (S)-2-octanol (ee = 98.2%), and (R)-2-octanol (ee = 98.5%) were all produced in high purity (>98%) and high yield (>90%). In addition to the two model substrates, this method could also be applied to the resolution of other aliphatic secondary alcohols.

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DO - 10.1016/j.tetasy.2013.01.018

M3 - 文章

AN - SCOPUS:84875222611

SN - 0957-4166

VL - 24

SP - 249

EP - 253

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 5-6

ER -

A green resolution-separation process for aliphatic secondary alcohols

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