A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant: Candida albicans infections

Dongliang Yang; Xinyi Lv; Lei Xue; Nan Yang; Yanling Hu; Lixing Weng; Nina Fu; Lianhui Wang; Xiaochen Dong

doi:10.1039/c9cc08463k

A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant: Candida albicans infections

Dongliang Yang, Xinyi Lv, Lei Xue, Nan Yang, Yanling Hu, Lixing Weng, Nina Fu, Lianhui Wang, Xiaochen Dong

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.

Original language	English
Pages (from-to)	15145-15148
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	100
DOIs	https://doi.org/10.1039/c9cc08463k
State	Published - 2019

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title = "A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant: Candida albicans infections",

abstract = "A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.",

author = "Dongliang Yang and Xinyi Lv and Lei Xue and Nan Yang and Yanling Hu and Lixing Weng and Nina Fu and Lianhui Wang and Xiaochen Dong",

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T1 - A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant

T2 - Candida albicans infections

AU - Yang, Dongliang

AU - Lv, Xinyi

AU - Xue, Lei

AU - Yang, Nan

AU - Hu, Yanling

AU - Weng, Lixing

AU - Fu, Nina

AU - Wang, Lianhui

AU - Dong, Xiaochen

PY - 2019

Y1 - 2019

N2 - A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.

AB - A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.

UR - http://www.scopus.com/inward/record.url?scp=85076446378&partnerID=8YFLogxK

U2 - 10.1039/c9cc08463k

DO - 10.1039/c9cc08463k

M3 - 文章

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AN - SCOPUS:85076446378

SN - 1359-7345

VL - 55

SP - 15145

EP - 15148

JO - Chemical Communications

JF - Chemical Communications

IS - 100

ER -

A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant: Candida albicans infections

Abstract

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