A quinoline-based fluorescent chemosensor for distinguishing cadmium from zinc ions using cysteine as an auxiliary reagent

Yang Ma, Fang Wang, Srinivasulu Kambam, Xiaoqiang Chen

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

A quinoline-based fluorescent chemosensor was reported for the simultaneous detection of Zn2+ and Cd2+ in aqueous solution. In HEPES buffer, among various metal ions, only Zn2+ and Cd2+ exhibited fluorescence enhancement at 497 nm accompanied by the red-shift emission wavelength. The mechanism was proposed that internal charge transfer effect induced by binding with Zn2+ or Cd2+ produced the fluorescence changes. With the addition of cysteine, the fluorescent solution containing sensor and Cd2+ show the decreased fluorescence at 497 nm and the increased fluorescence at 420 nm, which was attributed to the dissociation of the complex formed by sensor and Cd2+. In contrast, the fluorescence of solution containing sensor and Zn2+ is unchanged with the addition of Cys. Furthermore, the confocal microscopy experiments indicated that this sensor can provide real-time detection for intracellular Zn2+ and Cd2+.

Original languageEnglish
Pages (from-to)1116-1122
Number of pages7
JournalSensors and Actuators B: Chemical
Volume188
DOIs
StatePublished - 2013

Keywords

  • Biological imaging
  • Cysteine
  • Fluorescent sensor
  • Quinoline-based derivative
  • Zn/Cd ions

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