A regular nanostructured dithiolene metal complex film for ultrasensitive biosensing of liver enzyme

Danfeng Jiang; Cuiping Li; Tao Liu; Linlin Li; Zhenyu Chu; Wanqin Jin; Xiaoming Ren

doi:10.1016/j.snb.2016.10.122

A regular nanostructured dithiolene metal complex film for ultrasensitive biosensing of liver enzyme

Danfeng Jiang, Cuiping Li, Tao Liu, Linlin Li, Zhenyu Chu, Wanqin Jin, Xiaoming Ren

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A novel ultrasensitive biosensor was constructed by the [TBA]₂[Ni(mnt)₂]/graphene (mnt = maleonitriledithiolate) composite film for the detections of glutamate and alanine aminotransferase (ALT). The [TBA]₂[Ni(mnt)₂] nanocubes with a dimension of 500 nm were in-situ crystallized on the surface of Au electrode modified using thiol graphene in advance. Due to the synergistic effect between the electrocatalysis of [Ni(mnt)₂]²⁻ anion and the excellent conductivity of graphene, the as-prepared biosensors showed remarkably reversible electrochemical redox and stability. It exhibited high sensitivities of 27.32 μA mM⁻¹ cm⁻² and 0.636 nA μM⁻¹ for the biosensing of glutamate and ALT with the corresponding wide linear ranges of 10–600 μM⁻¹ and 5–140 U L⁻¹, respectively. This high performance ALT biosensor is promising application in the trace analysis of more physiological substances, and the successful adoption of [TBA]₂[Ni(mnt)₂] material in the biosensor construction can arouse more dithiolene metal complexes in the further application of electrocatalysis.

Original language	English
Pages (from-to)	860-867
Number of pages	8
Journal	Sensors and Actuators B: Chemical
Volume	241
DOIs	https://doi.org/10.1016/j.snb.2016.10.122
State	Published - 31 Mar 2017

Keywords

Dithiolene metal complexes
High sensitivity
Thiol graphene

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10.1016/j.snb.2016.10.122

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title = "A regular nanostructured dithiolene metal complex film for ultrasensitive biosensing of liver enzyme",

abstract = "A novel ultrasensitive biosensor was constructed by the [TBA]2[Ni(mnt)2]/graphene (mnt = maleonitriledithiolate) composite film for the detections of glutamate and alanine aminotransferase (ALT). The [TBA]2[Ni(mnt)2] nanocubes with a dimension of 500 nm were in-situ crystallized on the surface of Au electrode modified using thiol graphene in advance. Due to the synergistic effect between the electrocatalysis of [Ni(mnt)2]2− anion and the excellent conductivity of graphene, the as-prepared biosensors showed remarkably reversible electrochemical redox and stability. It exhibited high sensitivities of 27.32 μA mM−1 cm−2 and 0.636 nA μM−1 for the biosensing of glutamate and ALT with the corresponding wide linear ranges of 10–600 μM−1 and 5–140 U L−1, respectively. This high performance ALT biosensor is promising application in the trace analysis of more physiological substances, and the successful adoption of [TBA]2[Ni(mnt)2] material in the biosensor construction can arouse more dithiolene metal complexes in the further application of electrocatalysis.",

keywords = "Dithiolene metal complexes, High sensitivity, Thiol graphene",

author = "Danfeng Jiang and Cuiping Li and Tao Liu and Linlin Li and Zhenyu Chu and Wanqin Jin and Xiaoming Ren",

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AU - Jiang, Danfeng

AU - Li, Cuiping

AU - Liu, Tao

AU - Li, Linlin

AU - Chu, Zhenyu

AU - Jin, Wanqin

AU - Ren, Xiaoming

PY - 2017/3/31

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N2 - A novel ultrasensitive biosensor was constructed by the [TBA]2[Ni(mnt)2]/graphene (mnt = maleonitriledithiolate) composite film for the detections of glutamate and alanine aminotransferase (ALT). The [TBA]2[Ni(mnt)2] nanocubes with a dimension of 500 nm were in-situ crystallized on the surface of Au electrode modified using thiol graphene in advance. Due to the synergistic effect between the electrocatalysis of [Ni(mnt)2]2− anion and the excellent conductivity of graphene, the as-prepared biosensors showed remarkably reversible electrochemical redox and stability. It exhibited high sensitivities of 27.32 μA mM−1 cm−2 and 0.636 nA μM−1 for the biosensing of glutamate and ALT with the corresponding wide linear ranges of 10–600 μM−1 and 5–140 U L−1, respectively. This high performance ALT biosensor is promising application in the trace analysis of more physiological substances, and the successful adoption of [TBA]2[Ni(mnt)2] material in the biosensor construction can arouse more dithiolene metal complexes in the further application of electrocatalysis.

AB - A novel ultrasensitive biosensor was constructed by the [TBA]2[Ni(mnt)2]/graphene (mnt = maleonitriledithiolate) composite film for the detections of glutamate and alanine aminotransferase (ALT). The [TBA]2[Ni(mnt)2] nanocubes with a dimension of 500 nm were in-situ crystallized on the surface of Au electrode modified using thiol graphene in advance. Due to the synergistic effect between the electrocatalysis of [Ni(mnt)2]2− anion and the excellent conductivity of graphene, the as-prepared biosensors showed remarkably reversible electrochemical redox and stability. It exhibited high sensitivities of 27.32 μA mM−1 cm−2 and 0.636 nA μM−1 for the biosensing of glutamate and ALT with the corresponding wide linear ranges of 10–600 μM−1 and 5–140 U L−1, respectively. This high performance ALT biosensor is promising application in the trace analysis of more physiological substances, and the successful adoption of [TBA]2[Ni(mnt)2] material in the biosensor construction can arouse more dithiolene metal complexes in the further application of electrocatalysis.

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A regular nanostructured dithiolene metal complex film for ultrasensitive biosensing of liver enzyme

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