Access to Unsymmetric m-Terphenyl Derivatives via Ligand-Promoted Pd-Catalyzed Remote meta-C-H Arylation

Achieving high meta-selective C-H arylation of electron-poor benzoic acid derivatives is still a daunting challenge, which could be an efficient protocol to construct unsymmetrical 1,3-disubstituted benzene derivatives. Herein, we report the ligand-promoted high meta-selective C-H arylation of benzoic acid derivatives. A wide range of unsymmetric and unfunctionalized 1,3-disubstituted benzene derivatives were obtained. This strategy not only provided a facile, modular, and robust approach to various unsymmetrical 1,3-disubstituted benzene derivatives but also demonstrated the potential of remote C-H functionalization of other electron-poor substrates.