TY - JOUR
T1 - Achieving Ultrasmall Prussian Blue Nanoparticles as High-Performance Biomedical Agents with Multifunctions
AU - Qin, Zhiguo
AU - Chen, Bo
AU - Mao, Yu
AU - Shi, Chu
AU - Li, Yan
AU - Huang, Xiao
AU - Yang, Fang
AU - Gu, Ning
N1 - Publisher Copyright:
©
PY - 2020/12/23
Y1 - 2020/12/23
N2 - Prussian blue nanoparticles (PBNPs), which belong to the iron-based metal-organic frameworks, are important biomedical agents. Reducing the size of PBNPs can bring improved functional properties, but unfortunately, has been a long-standing challenge. Herein, sub-5 nm ultrasmall PBNPs (USPBNPs) were successfully synthesized by using ethanol/water mixture as the solvent and polyvinyl pyrrolidone (PVP) as the surface capping agent. Adjusting the ethanol/water ratio is not only able to control the nucleation time and size of PBNPs but also tune the conformation of PVP molecules so as to prevent interparticle attachment and enlargement. At an ethanol/water ratio of 3:1, highly stable USPBNPs with a size of ∼3.4 nm were synthesized. Due to their large specific surface area, they demonstrated high peroxidase-like and catalase-like activities, which outperform PBNPs synthesized by a conventional method. In addition, they also showed a high longitudinal relaxation rate (r1) of 1.3 mM-1 S-1, suggesting their potential to be used as T1 MRI agent.
AB - Prussian blue nanoparticles (PBNPs), which belong to the iron-based metal-organic frameworks, are important biomedical agents. Reducing the size of PBNPs can bring improved functional properties, but unfortunately, has been a long-standing challenge. Herein, sub-5 nm ultrasmall PBNPs (USPBNPs) were successfully synthesized by using ethanol/water mixture as the solvent and polyvinyl pyrrolidone (PVP) as the surface capping agent. Adjusting the ethanol/water ratio is not only able to control the nucleation time and size of PBNPs but also tune the conformation of PVP molecules so as to prevent interparticle attachment and enlargement. At an ethanol/water ratio of 3:1, highly stable USPBNPs with a size of ∼3.4 nm were synthesized. Due to their large specific surface area, they demonstrated high peroxidase-like and catalase-like activities, which outperform PBNPs synthesized by a conventional method. In addition, they also showed a high longitudinal relaxation rate (r1) of 1.3 mM-1 S-1, suggesting their potential to be used as T1 MRI agent.
KW - magnetic resonance imaging
KW - nanozyme activities
KW - radical scavenging
KW - solvent effect
KW - ultrasmall Prussian blue nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85097770987&partnerID=8YFLogxK
U2 - 10.1021/acsami.0c18357
DO - 10.1021/acsami.0c18357
M3 - 文章
C2 - 33295749
AN - SCOPUS:85097770987
SN - 1944-8244
VL - 12
SP - 57382
EP - 57390
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 51
ER -