TY - JOUR
T1 - Acute toxicity effect of bisphenol a and its analogues on adult and embryo of Zebrafish
AU - Ren, Wen Juan
AU - Wang, Zhen
AU - Yang, Xian Hai
AU - Liu, Ji Ning
AU - Yang, Qian
AU - Chen, Ying Wen
AU - Shen, Shu Bao
N1 - Publisher Copyright:
© 2017, China Environmental Science Press. All rights reserved.
PY - 2017/4/25
Y1 - 2017/4/25
N2 - Little is known so far about toxicities of bisphenol B(BPB), bisphenol F(BPF), bisphenol AP(BPAP), bisphenol AF(BPAF), bisphenol Z(BPZ), bisphenol P(BPP), bisphenol S (BPS), although they have been used widely as BPA substitutes. A comparative study was done by exposing adults and embryos of zebrafish to the 8 kinds of chemicals for 24, 48, 72 and 96 hours to determine half lethal concentration (LC50) and fatality rate at different time intervals. Results show that the toxicities of bisphenol A and its analogues to adult zebrafish were linearly related to their respective ones to zebrafish embryos. According to the criteria for grading of toxicity in “Rules for Classification and Labeling of Chemicals, Part 28: Hazardous to the Aquatic Environment”, BPP is sorted into Grade I in toxicity and BPA, BPB, BPF, BPZ, BPAP and BPAF into Grade II, while according to the Verhaar classification system, bisphenol A and its analogues belong to the category of chemicals with anesthetic toxication mechanism and degree of their toxicities is related to hydrophobic groups.
AB - Little is known so far about toxicities of bisphenol B(BPB), bisphenol F(BPF), bisphenol AP(BPAP), bisphenol AF(BPAF), bisphenol Z(BPZ), bisphenol P(BPP), bisphenol S (BPS), although they have been used widely as BPA substitutes. A comparative study was done by exposing adults and embryos of zebrafish to the 8 kinds of chemicals for 24, 48, 72 and 96 hours to determine half lethal concentration (LC50) and fatality rate at different time intervals. Results show that the toxicities of bisphenol A and its analogues to adult zebrafish were linearly related to their respective ones to zebrafish embryos. According to the criteria for grading of toxicity in “Rules for Classification and Labeling of Chemicals, Part 28: Hazardous to the Aquatic Environment”, BPP is sorted into Grade I in toxicity and BPA, BPB, BPF, BPZ, BPAP and BPAF into Grade II, while according to the Verhaar classification system, bisphenol A and its analogues belong to the category of chemicals with anesthetic toxication mechanism and degree of their toxicities is related to hydrophobic groups.
KW - Acute toxicity
KW - Bisphenol A and its analogue
KW - Deformity
KW - Median lethal concentration (LC)
UR - http://www.scopus.com/inward/record.url?scp=85042521904&partnerID=8YFLogxK
U2 - 10.11934/j.issn.1673-4831.2017.04.011
DO - 10.11934/j.issn.1673-4831.2017.04.011
M3 - 文章
AN - SCOPUS:85042521904
SN - 1673-4831
VL - 33
SP - 372
EP - 378
JO - Journal of Ecology and Rural Environment
JF - Journal of Ecology and Rural Environment
IS - 4
ER -