Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

Xiuli Zhong; Qing Yang; Yingshuang Chen; Yuliang Jiang; Zhihui Dai

doi:10.1039/d0tb01496f

Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

Xiuli Zhong, Qing Yang, Yingshuang Chen, Yuliang Jiang, Zhihui Dai

Nanjing Normal University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Hypochlorite is an important active oxygen species formed in living organisms, and rapid and highly sensitive detection of trace hypochlorite is of great significance for understanding the mechanism of diseases caused by abnormal hypochlorite concentrations at an early stage. Although aggregation-induced emission (AIE) probes are highly important for analyte de-tection in living organisms, there is a lack of AIE probes for hypochlorite detection. In this study, two AIE probes based on benzothiazole derivatives (BTD-1 and BTD-2) were designed and synthesized. Both probes exhibited good AIE charac-teristics and allowed different visual detection for hypochlorite. Additionally, the two probes could be used to detect endogenous hypochlorite in mitochondria and were successfully applied for in vivo hypochlorite imaging in zebrafish.

Original language	English
Pages (from-to)	7375-7381
Number of pages	7
Journal	Journal of Materials Chemistry B
Volume	8
Issue number	33
DOIs	https://doi.org/10.1039/d0tb01496f
State	Published - 7 Sep 2020
Externally published	Yes

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abstract = "Hypochlorite is an important active oxygen species formed in living organisms, and rapid and highly sensitive detection of trace hypochlorite is of great significance for understanding the mechanism of diseases caused by abnormal hypochlorite concentrations at an early stage. Although aggregation-induced emission (AIE) probes are highly important for analyte de-tection in living organisms, there is a lack of AIE probes for hypochlorite detection. In this study, two AIE probes based on benzothiazole derivatives (BTD-1 and BTD-2) were designed and synthesized. Both probes exhibited good AIE charac-teristics and allowed different visual detection for hypochlorite. Additionally, the two probes could be used to detect endogenous hypochlorite in mitochondria and were successfully applied for in vivo hypochlorite imaging in zebrafish.",

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T1 - Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

AU - Zhong, Xiuli

AU - Yang, Qing

AU - Chen, Yingshuang

AU - Jiang, Yuliang

AU - Dai, Zhihui

PY - 2020/9/7

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AB - Hypochlorite is an important active oxygen species formed in living organisms, and rapid and highly sensitive detection of trace hypochlorite is of great significance for understanding the mechanism of diseases caused by abnormal hypochlorite concentrations at an early stage. Although aggregation-induced emission (AIE) probes are highly important for analyte de-tection in living organisms, there is a lack of AIE probes for hypochlorite detection. In this study, two AIE probes based on benzothiazole derivatives (BTD-1 and BTD-2) were designed and synthesized. Both probes exhibited good AIE charac-teristics and allowed different visual detection for hypochlorite. Additionally, the two probes could be used to detect endogenous hypochlorite in mitochondria and were successfully applied for in vivo hypochlorite imaging in zebrafish.

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Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish

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