Allylation of Lactol in Water

Mengxue Zheng; Wenxiu Gao; Lei Zhang; Kaiyu Yan; Zhenguo Zhang; Peizhong Xie; Teck Peng Loh

doi:10.1021/acs.orglett.4c04189

Allylation of Lactol in Water

Mengxue Zheng, Wenxiu Gao, Lei Zhang, Kaiyu Yan, Zhenguo Zhang, Peizhong Xie, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

Original language	English
Pages (from-to)	10201-10206
Number of pages	6
Journal	Organic Letters
Volume	26
Issue number	47
DOIs	https://doi.org/10.1021/acs.orglett.4c04189
State	Published - 29 Nov 2024

Access to Document

10.1021/acs.orglett.4c04189

Cite this

@article{352517b509244caea0dd6a53ae3d71a1,

title = "Allylation of Lactol in Water",

abstract = "We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.",

author = "Mengxue Zheng and Wenxiu Gao and Lei Zhang and Kaiyu Yan and Zhenguo Zhang and Peizhong Xie and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society.",

year = "2024",

month = nov,

day = "29",

doi = "10.1021/acs.orglett.4c04189",

language = "英语",

volume = "26",

pages = "10201--10206",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "47",

}

TY - JOUR

T1 - Allylation of Lactol in Water

AU - Zheng, Mengxue

AU - Gao, Wenxiu

AU - Zhang, Lei

AU - Yan, Kaiyu

AU - Zhang, Zhenguo

AU - Xie, Peizhong

AU - Loh, Teck Peng

PY - 2024/11/29

Y1 - 2024/11/29

N2 - We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

AB - We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

UR - http://www.scopus.com/inward/record.url?scp=85209896738&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.4c04189

DO - 10.1021/acs.orglett.4c04189

M3 - 文章

C2 - 39565036

AN - SCOPUS:85209896738

SN - 1523-7060

VL - 26

SP - 10201

EP - 10206

JO - Organic Letters

JF - Organic Letters

IS - 47

ER -

Allylation of Lactol in Water

Abstract

Access to Document

Other files and links

Fingerprint

Cite this