TY - JOUR
T1 - An improved method for the synthesis of phenylacetic acid derivatives via carbonylation
AU - Li, He
AU - Zhang, Yijun
AU - Liu, Dinghua
AU - Liu, Xiaoqin
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - 2,4-Dichlorophenylacetic acid is synthesized in high yield via the carbonylation of 2,4-dichlorobenzyl chloride, and various experimental conditions are evaluated. Xylene, bistriphenylphosphine palladium dichloride, tetraethylammonium chloride and sodium hydroxide in solution are added to the reaction system and held at 80 °C under a CO atmosphere. 2,4-Dichlorophenylacetic acid is obtained in a maximum yield of 95%, and a mechanism for 2,4-dichlorobenzyl chloride carbonylation is proposed. The reaction system provides a mild, effective and novel means by which to prepare phenylacetic acid derivatives from their corresponding benzyl chloride derivatives.
AB - 2,4-Dichlorophenylacetic acid is synthesized in high yield via the carbonylation of 2,4-dichlorobenzyl chloride, and various experimental conditions are evaluated. Xylene, bistriphenylphosphine palladium dichloride, tetraethylammonium chloride and sodium hydroxide in solution are added to the reaction system and held at 80 °C under a CO atmosphere. 2,4-Dichlorophenylacetic acid is obtained in a maximum yield of 95%, and a mechanism for 2,4-dichlorobenzyl chloride carbonylation is proposed. The reaction system provides a mild, effective and novel means by which to prepare phenylacetic acid derivatives from their corresponding benzyl chloride derivatives.
KW - benzyl chloride derivatives
KW - carbonylation
KW - palladium catalyst
KW - phase-transfer catalysis
KW - phenylacetic acid derivatives
UR - http://www.scopus.com/inward/record.url?scp=85074582682&partnerID=8YFLogxK
U2 - 10.1177/1747519819876202
DO - 10.1177/1747519819876202
M3 - 文章
AN - SCOPUS:85074582682
SN - 1747-5198
VL - 43
SP - 548
EP - 552
JO - Journal of Chemical Research
JF - Journal of Chemical Research
IS - 11-12
ER -