An NBD fluorophore-based colorimetric and fluorescent chemosensor for hydrogen sulfide and its application for bioimaging

Guodong Zhou, Huilin Wang, Yang Ma, Xiaoqiang Chen

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Hydrogen sulfide (H2S) is an important gaseous mediator in cellular physiology and pathology. For understanding the biological action of H2S to both healthy and disease states, it is important to develop H2S-selective sensor. Herein we report a colorimetric and fluorescent probe, which employs an NBD moiety as fluorophore, and is equipped with azide group as H2S-active unit. The probe exhibits selective and sensitive response to H2S in aqueous solution. By employing 1 mM sensor, the detection limit was evaluated to be 680 nM with a signal-to-noise ratio of 3. Confocal microscopy imaging experiments demonstrate the probe has potential as a powerful tool for the imaging of hydrogen sulfide in living cells. Crown

Original languageEnglish
Pages (from-to)867-870
Number of pages4
JournalTetrahedron
Volume69
Issue number2
DOIs
StatePublished - 14 Jan 2013

Keywords

  • 3-diazole (NBD)
  • 7-nitrobenz-2-oxa-1
  • Bioimaging
  • Fluorescent sensor
  • Hydrogen sulfide

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