An S2- responsive nanocontainer for inhibiting microbial corrosion caused by sulfate-reducing bacteria

Ruonan Tang, Xiao Wang, Zhihao Chen, Ying Liu, Wenzhong Yang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Controlled-release materials were ideal for improving drug utilization and reducing environmental pollution. In this study, Metronidazole @ Zeolite imidazole backbone − 8 nanocontainers (MNZ@ZIF-8) with high drug loading (59.8 mg/g) and S2 - specific response were prepared by co-precipitation method. Material characterization showed that MNZ was successfully loaded into ZIF-8 and that MNZ@ZIF-8 showed excellent S2- responsiveness in drug release experiments. The MNZ release rate increased significantly when the S2- concentration was greater than 0.5 mM, and the cumulative release of MNZ was even as high as 90.8% at the S2- concentration of 5 mM. The release kinetics of MNZ@ZIF-8 was consistent with the non-Fickian diffusion mechanism of the Korsmeyer-Peppas model. The bactericidal effect of MNZ@ZIF-8 was evaluated in sulfate-reducing bacteria (SRB) medium. The nanocontainer showed 100% antibacterial effect of SRB at a concentration of 300 μg mL−1. With the increase of nanocontainer concentration, the depth of corrosion pits on the surface of Q235 test pieces gradually decreased until disappeared (300 μg mL−1). This novel drug release system had various functions such as the simple synthesis process, antibacterial, and S2- specific response, which provided an idea for the development of drug release system with S2- as the response condition.

Original languageEnglish
Article number131110
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume663
DOIs
StatePublished - 20 Apr 2023

Keywords

  • Metronidazole
  • Microbial corrosion
  • S responsive nanocontainers
  • Sulfate-reducing bacteria
  • Zeolitic imidazole framework-8

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