TY - JOUR
T1 - An S2- responsive nanocontainer for inhibiting microbial corrosion caused by sulfate-reducing bacteria
AU - Tang, Ruonan
AU - Wang, Xiao
AU - Chen, Zhihao
AU - Liu, Ying
AU - Yang, Wenzhong
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/4/20
Y1 - 2023/4/20
N2 - Controlled-release materials were ideal for improving drug utilization and reducing environmental pollution. In this study, Metronidazole @ Zeolite imidazole backbone − 8 nanocontainers (MNZ@ZIF-8) with high drug loading (59.8 mg/g) and S2 - specific response were prepared by co-precipitation method. Material characterization showed that MNZ was successfully loaded into ZIF-8 and that MNZ@ZIF-8 showed excellent S2- responsiveness in drug release experiments. The MNZ release rate increased significantly when the S2- concentration was greater than 0.5 mM, and the cumulative release of MNZ was even as high as 90.8% at the S2- concentration of 5 mM. The release kinetics of MNZ@ZIF-8 was consistent with the non-Fickian diffusion mechanism of the Korsmeyer-Peppas model. The bactericidal effect of MNZ@ZIF-8 was evaluated in sulfate-reducing bacteria (SRB) medium. The nanocontainer showed 100% antibacterial effect of SRB at a concentration of 300 μg mL−1. With the increase of nanocontainer concentration, the depth of corrosion pits on the surface of Q235 test pieces gradually decreased until disappeared (300 μg mL−1). This novel drug release system had various functions such as the simple synthesis process, antibacterial, and S2- specific response, which provided an idea for the development of drug release system with S2- as the response condition.
AB - Controlled-release materials were ideal for improving drug utilization and reducing environmental pollution. In this study, Metronidazole @ Zeolite imidazole backbone − 8 nanocontainers (MNZ@ZIF-8) with high drug loading (59.8 mg/g) and S2 - specific response were prepared by co-precipitation method. Material characterization showed that MNZ was successfully loaded into ZIF-8 and that MNZ@ZIF-8 showed excellent S2- responsiveness in drug release experiments. The MNZ release rate increased significantly when the S2- concentration was greater than 0.5 mM, and the cumulative release of MNZ was even as high as 90.8% at the S2- concentration of 5 mM. The release kinetics of MNZ@ZIF-8 was consistent with the non-Fickian diffusion mechanism of the Korsmeyer-Peppas model. The bactericidal effect of MNZ@ZIF-8 was evaluated in sulfate-reducing bacteria (SRB) medium. The nanocontainer showed 100% antibacterial effect of SRB at a concentration of 300 μg mL−1. With the increase of nanocontainer concentration, the depth of corrosion pits on the surface of Q235 test pieces gradually decreased until disappeared (300 μg mL−1). This novel drug release system had various functions such as the simple synthesis process, antibacterial, and S2- specific response, which provided an idea for the development of drug release system with S2- as the response condition.
KW - Metronidazole
KW - Microbial corrosion
KW - S responsive nanocontainers
KW - Sulfate-reducing bacteria
KW - Zeolitic imidazole framework-8
UR - http://www.scopus.com/inward/record.url?scp=85147840890&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfa.2023.131110
DO - 10.1016/j.colsurfa.2023.131110
M3 - 文章
AN - SCOPUS:85147840890
SN - 0927-7757
VL - 663
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
M1 - 131110
ER -