Asymmetric P-C bond formation: Diastereoselective synthesis of adjacent P,C-stereogenic allylic phosphorus compounds

A novel catalytic asymmetric P-C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P,C-stereogenic phosphorus compounds in high yields with high regio- and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched (S_P)-phosphinates through kinetic resolution. New strategy for adjacent P,C-stereogenic phosphorus compounds: A novel catalytic asymmetric P-C bond formation between phosphinates/phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P,C-stereogenic phosphorus compounds in high yields with high regio- and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched (S_P)-phosphinates through kinetic resolution.