Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes

Xiaobo Wang; Xiaoqiang Chen; Lei Xing; Chun Mao; Hongxing Yu; Jian Shen

doi:10.1039/c3tb20855a

Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes

Xiaobo Wang, Xiaoqiang Chen, Lei Xing, Chun Mao, Hongxing Yu, Jian Shen

COLLEGE OF CHEMICAL ENGINEERING

Nanjing Normal University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Different approaches have been used in developing new coronary stents to protect against thrombosis and minimize restenosis. Here we describe a new zwitterionic bare metal stent (BMS) surface based on 2-((bromobutyryl)oxy)ethyl acrylate (BBEA) hyperbranched polymer. The new BMS produced was studied for its blood compatibility. The hemocompatibility studied including platelet adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, plasma recalcification time (PRT) assay, complement activation, and platelet activation at the molecular level. Moreover the cytotoxicity of BMS before and after modification was also characterized by MTT assays. Most assays had remarkable differences in the presence of the new zwitterionic BMS, indicating the importance of the zwitterion.

Original language	English
Pages (from-to)	5036-5044
Number of pages	9
Journal	Journal of Materials Chemistry B
Volume	1
Issue number	38
DOIs	https://doi.org/10.1039/c3tb20855a
State	Published - 14 Oct 2013

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abstract = "Different approaches have been used in developing new coronary stents to protect against thrombosis and minimize restenosis. Here we describe a new zwitterionic bare metal stent (BMS) surface based on 2-((bromobutyryl)oxy)ethyl acrylate (BBEA) hyperbranched polymer. The new BMS produced was studied for its blood compatibility. The hemocompatibility studied including platelet adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, plasma recalcification time (PRT) assay, complement activation, and platelet activation at the molecular level. Moreover the cytotoxicity of BMS before and after modification was also characterized by MTT assays. Most assays had remarkable differences in the presence of the new zwitterionic BMS, indicating the importance of the zwitterion.",

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AU - Wang, Xiaobo

AU - Chen, Xiaoqiang

AU - Xing, Lei

AU - Mao, Chun

AU - Yu, Hongxing

AU - Shen, Jian

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AB - Different approaches have been used in developing new coronary stents to protect against thrombosis and minimize restenosis. Here we describe a new zwitterionic bare metal stent (BMS) surface based on 2-((bromobutyryl)oxy)ethyl acrylate (BBEA) hyperbranched polymer. The new BMS produced was studied for its blood compatibility. The hemocompatibility studied including platelet adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, plasma recalcification time (PRT) assay, complement activation, and platelet activation at the molecular level. Moreover the cytotoxicity of BMS before and after modification was also characterized by MTT assays. Most assays had remarkable differences in the presence of the new zwitterionic BMS, indicating the importance of the zwitterion.

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Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes

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