Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

Yu Cai; Qianyun Tang; Xiujuan Wu; Weili Si; Qi Zhang; Wei Huang; Xiaochen Dong

doi:10.1021/acsami.6b01533

Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

Yu Cai, Qianyun Tang, Xiujuan Wu, Weili Si, Qi Zhang, Wei Huang, Xiaochen Dong

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.

Original language	English
Pages (from-to)	10737-10742
Number of pages	6
Journal	ACS Applied Materials and Interfaces
Volume	8
Issue number	17
DOIs	https://doi.org/10.1021/acsami.6b01533
State	Published - 4 May 2016

Keywords

bromo-substituted
diketopyrrolopyrrole
hyaluronic acid
photodynamic therapy
photosensitizers

Access to Document

10.1021/acsami.6b01533

Cite this

@article{2e08e117fe9f40c7806729d5172597e4,

title = "Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy",

abstract = "Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.",

keywords = "bromo-substituted, diketopyrrolopyrrole, hyaluronic acid, photodynamic therapy, photosensitizers",

author = "Yu Cai and Qianyun Tang and Xiujuan Wu and Weili Si and Qi Zhang and Wei Huang and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = may,

day = "4",

doi = "10.1021/acsami.6b01533",

language = "英语",

volume = "8",

pages = "10737--10742",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "17",

}

TY - JOUR

T1 - Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

AU - Cai, Yu

AU - Tang, Qianyun

AU - Wu, Xiujuan

AU - Si, Weili

AU - Zhang, Qi

AU - Huang, Wei

AU - Dong, Xiaochen

PY - 2016/5/4

Y1 - 2016/5/4

N2 - Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.

AB - Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.

KW - bromo-substituted

KW - diketopyrrolopyrrole

KW - hyaluronic acid

KW - photodynamic therapy

KW - photosensitizers

UR - http://www.scopus.com/inward/record.url?scp=84969705194&partnerID=8YFLogxK

U2 - 10.1021/acsami.6b01533

DO - 10.1021/acsami.6b01533

M3 - 文章

C2 - 27064605

AN - SCOPUS:84969705194

SN - 1944-8244

VL - 8

SP - 10737

EP - 10742

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 17

ER -

Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this