Butyric acid: Applications and recent advances in its bioproduction

Ling Jiang; Hongxin Fu; Hopen K. Yang; Wei Xu; Jufang Wang; Shang Tian Yang

doi:10.1016/j.biotechadv.2018.09.005

Butyric acid: Applications and recent advances in its bioproduction

Ling Jiang, Hongxin Fu, Hopen K. Yang, Wei Xu, Jufang Wang, Shang Tian Yang

COLLEGE OF FOOD SCIENCE AND LIGHT INDUSTRY

Research output: Contribution to journal › Review article › peer-review

138 Scopus citations

Abstract

Butyric acid is an important C4 organic acid with broad applications. It is currently produced by chemosynthesis from petroleum-based feedstocks. However, the fermentative production of butyric acid from renewable feedstocks has received growing attention because of consumer demand for green products and natural ingredients in foods, pharmaceuticals, animal feed supplements, and cosmetics. In this review, strategies for improving microbial butyric acid production, including strain engineering and novel fermentation process development are discussed and compared regarding product yield, titer, purity and productivity. Future perspectives on strain and process improvements for butyric acid production are also discussed.

Original language	English
Pages (from-to)	2101-2117
Number of pages	17
Journal	Biotechnology Advances
Volume	36
Issue number	8
DOIs	https://doi.org/10.1016/j.biotechadv.2018.09.005
State	Published - Dec 2018

Keywords

Butyric acid
Clostridia
Fermentation
Metabolic engineering
Product recovery
Renewable feedstock

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biotechadv.2018.09.005

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title = "Butyric acid: Applications and recent advances in its bioproduction",

abstract = "Butyric acid is an important C4 organic acid with broad applications. It is currently produced by chemosynthesis from petroleum-based feedstocks. However, the fermentative production of butyric acid from renewable feedstocks has received growing attention because of consumer demand for green products and natural ingredients in foods, pharmaceuticals, animal feed supplements, and cosmetics. In this review, strategies for improving microbial butyric acid production, including strain engineering and novel fermentation process development are discussed and compared regarding product yield, titer, purity and productivity. Future perspectives on strain and process improvements for butyric acid production are also discussed.",

keywords = "Butyric acid, Clostridia, Fermentation, Metabolic engineering, Product recovery, Renewable feedstock",

author = "Ling Jiang and Hongxin Fu and Yang, {Hopen K.} and Wei Xu and Jufang Wang and Yang, {Shang Tian}",

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T2 - Applications and recent advances in its bioproduction

AU - Jiang, Ling

AU - Fu, Hongxin

AU - Yang, Hopen K.

AU - Xu, Wei

AU - Wang, Jufang

AU - Yang, Shang Tian

PY - 2018/12

Y1 - 2018/12

N2 - Butyric acid is an important C4 organic acid with broad applications. It is currently produced by chemosynthesis from petroleum-based feedstocks. However, the fermentative production of butyric acid from renewable feedstocks has received growing attention because of consumer demand for green products and natural ingredients in foods, pharmaceuticals, animal feed supplements, and cosmetics. In this review, strategies for improving microbial butyric acid production, including strain engineering and novel fermentation process development are discussed and compared regarding product yield, titer, purity and productivity. Future perspectives on strain and process improvements for butyric acid production are also discussed.

AB - Butyric acid is an important C4 organic acid with broad applications. It is currently produced by chemosynthesis from petroleum-based feedstocks. However, the fermentative production of butyric acid from renewable feedstocks has received growing attention because of consumer demand for green products and natural ingredients in foods, pharmaceuticals, animal feed supplements, and cosmetics. In this review, strategies for improving microbial butyric acid production, including strain engineering and novel fermentation process development are discussed and compared regarding product yield, titer, purity and productivity. Future perspectives on strain and process improvements for butyric acid production are also discussed.

KW - Butyric acid

KW - Clostridia

KW - Fermentation

KW - Metabolic engineering

KW - Product recovery

KW - Renewable feedstock

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M3 - 文献综述

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AN - SCOPUS:85054135548

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JO - Biotechnology Advances

JF - Biotechnology Advances

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Butyric acid: Applications and recent advances in its bioproduction

Abstract

Keywords

UN SDGs

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