Cascade OFF-ON-OFF fluorescent probe: Dual detection of Fe3+ ions and thiols

Shimin Fan; Wenge Yang; Jianfeng Hao; Hongjie Li; Wangdan Zhao; Jian Zhang; Yonghong Hu

doi:10.1016/j.jphotochem.2016.05.017

Cascade OFF-ON-OFF fluorescent probe: Dual detection of Fe³⁺ ions and thiols

Shimin Fan, Wenge Yang, Jianfeng Hao, Hongjie Li, Wangdan Zhao, Jian Zhang, Yonghong Hu

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A new novel Rhodamine B-based fluorescent probe was synthesized for the selective cascade signaling of Fe³⁺ and thiols (glutathione, homo-cysteine, cysteine). Non-fluorescent rhodamine derivatives can selectively detect Fe³⁺ over some other metal ions in ethanol-water (4/1, v/v, pH 7.0) media, leading to prominent fluorescence OFF-ON switching. The obtained LDF-Fe³⁺ ensemble can subsequently serve as a sensitive and selective chemosensor for thiols, exhibiting complete signal quenching (fluorescence ON-OFF switching). The practical use of its Fe³⁺ ions ensemble was demonstrated by its application to the detection of thiols in the living cells.

Original language	English
Pages (from-to)	129-135
Number of pages	7
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	328
DOIs	https://doi.org/10.1016/j.jphotochem.2016.05.017
State	Published - 1 Sep 2016

Keywords

Fe ions
Hela Cells
Rhodamine
Thiols

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10.1016/j.jphotochem.2016.05.017

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title = "Cascade OFF-ON-OFF fluorescent probe: Dual detection of Fe3+ ions and thiols",

abstract = "A new novel Rhodamine B-based fluorescent probe was synthesized for the selective cascade signaling of Fe3+ and thiols (glutathione, homo-cysteine, cysteine). Non-fluorescent rhodamine derivatives can selectively detect Fe3+ over some other metal ions in ethanol-water (4/1, v/v, pH 7.0) media, leading to prominent fluorescence OFF-ON switching. The obtained LDF-Fe3+ ensemble can subsequently serve as a sensitive and selective chemosensor for thiols, exhibiting complete signal quenching (fluorescence ON-OFF switching). The practical use of its Fe3+ ions ensemble was demonstrated by its application to the detection of thiols in the living cells.",

keywords = "Fe ions, Hela Cells, Rhodamine, Thiols",

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TY - JOUR

T1 - Cascade OFF-ON-OFF fluorescent probe

T2 - Dual detection of Fe3+ ions and thiols

AU - Fan, Shimin

AU - Yang, Wenge

AU - Hao, Jianfeng

AU - Li, Hongjie

AU - Zhao, Wangdan

AU - Zhang, Jian

AU - Hu, Yonghong

PY - 2016/9/1

Y1 - 2016/9/1

N2 - A new novel Rhodamine B-based fluorescent probe was synthesized for the selective cascade signaling of Fe3+ and thiols (glutathione, homo-cysteine, cysteine). Non-fluorescent rhodamine derivatives can selectively detect Fe3+ over some other metal ions in ethanol-water (4/1, v/v, pH 7.0) media, leading to prominent fluorescence OFF-ON switching. The obtained LDF-Fe3+ ensemble can subsequently serve as a sensitive and selective chemosensor for thiols, exhibiting complete signal quenching (fluorescence ON-OFF switching). The practical use of its Fe3+ ions ensemble was demonstrated by its application to the detection of thiols in the living cells.

AB - A new novel Rhodamine B-based fluorescent probe was synthesized for the selective cascade signaling of Fe3+ and thiols (glutathione, homo-cysteine, cysteine). Non-fluorescent rhodamine derivatives can selectively detect Fe3+ over some other metal ions in ethanol-water (4/1, v/v, pH 7.0) media, leading to prominent fluorescence OFF-ON switching. The obtained LDF-Fe3+ ensemble can subsequently serve as a sensitive and selective chemosensor for thiols, exhibiting complete signal quenching (fluorescence ON-OFF switching). The practical use of its Fe3+ ions ensemble was demonstrated by its application to the detection of thiols in the living cells.

KW - Fe ions

KW - Hela Cells

KW - Rhodamine

KW - Thiols

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DO - 10.1016/j.jphotochem.2016.05.017

M3 - 文章

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SN - 1010-6030

VL - 328

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EP - 135

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

ER -

Cascade OFF-ON-OFF fluorescent probe: Dual detection of Fe³⁺ ions and thiols

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Keywords

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