TY - JOUR
T1 - Construction of stable microbial consortia for effective biochemical synthesis
AU - Jiang, Yujia
AU - Wu, Ruofan
AU - Zhang, Wenming
AU - Xin, Fengxue
AU - Jiang, Min
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/11
Y1 - 2023/11
N2 - Microbial consortia can complete otherwise arduous tasks through the cooperation of multiple microbial species. This concept has been applied to produce commodity chemicals, natural products, and biofuels. However, metabolite incompatibility and growth competition can make the microbial composition unstable, and fluctuating microbial populations reduce the efficiency of chemical production. Thus, controlling the populations and regulating the complex interactions between different strains are challenges in constructing stable microbial consortia. This Review discusses advances in synthetic biology and metabolic engineering to control social interactions within microbial cocultures, including substrate separation, byproduct elimination, crossfeeding, and quorum-sensing circuit design. Additionally, this Review addresses interdisciplinary strategies to improve the stability of microbial consortia and provides design principles for microbial consortia to enhance chemical production.
AB - Microbial consortia can complete otherwise arduous tasks through the cooperation of multiple microbial species. This concept has been applied to produce commodity chemicals, natural products, and biofuels. However, metabolite incompatibility and growth competition can make the microbial composition unstable, and fluctuating microbial populations reduce the efficiency of chemical production. Thus, controlling the populations and regulating the complex interactions between different strains are challenges in constructing stable microbial consortia. This Review discusses advances in synthetic biology and metabolic engineering to control social interactions within microbial cocultures, including substrate separation, byproduct elimination, crossfeeding, and quorum-sensing circuit design. Additionally, this Review addresses interdisciplinary strategies to improve the stability of microbial consortia and provides design principles for microbial consortia to enhance chemical production.
KW - crossfeeding
KW - interaction mechanisms
KW - microbial consortia
KW - quorum sensing
UR - http://www.scopus.com/inward/record.url?scp=85162856602&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2023.05.008
DO - 10.1016/j.tibtech.2023.05.008
M3 - 文献综述
C2 - 37330325
AN - SCOPUS:85162856602
SN - 0167-7799
VL - 41
SP - 1430
EP - 1441
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 11
ER -