Copper-catalyzed aerobic oxidative coupling of terminal alkynes with α-carbonyl aldehydes: An expedient approach toward ynediones

An efficient and mild one-pot approach for copper-catalyzed aerobic oxidative coupling of α-carbonyl aldehydes with terminal alkynes toward ynediones has been developed. Moreover, a variety of ynediones were constructed under the optimized reaction conditions, and a plausible mechanism was presented based on a series of control experiments.