Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes

Peng Wang; Xue Liang Yeo; Teck Peng Loh

doi:10.1021/ja109464u

Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes

Peng Wang, Xue Liang Yeo, Teck Peng Loh

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.

Original language	English
Pages (from-to)	1254-1256
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	133
Issue number	5
DOIs	https://doi.org/10.1021/ja109464u
State	Published - 9 Feb 2011
Externally published	Yes

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title = "Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes",

abstract = "A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.",

author = "Peng Wang and Yeo, {Xue Liang} and Loh, {Teck Peng}",

year = "2011",

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AU - Wang, Peng

AU - Yeo, Xue Liang

AU - Loh, Teck Peng

PY - 2011/2/9

Y1 - 2011/2/9

N2 - A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.

AB - A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.

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U2 - 10.1021/ja109464u

DO - 10.1021/ja109464u

M3 - 文章

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 5

ER -

Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes

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