Core–shell “loading-type” nanomaterials enabling glucometer readout for portable and sensitive detection of p-aminophenol in real samples

Xiang Ling Li, Lei Zhao, Zi Heng Wang, Tian Shun Song, Ting Guo, Jing Jing Xie

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A one-target-many-trigger signal model sensing strategy is proposed for quickly, sensitive and on-site detection of the environmental pollutant p-aminophenol (PAP) by use of a commercial personal glucose meter (PGM) for signal readout with the core–shell “loading-type” nanomaterial MSNs@MnO2 as amplifiable nanoprobes. In this design, the mesoporous silica nanoparticles (MSNs) nanocontainer with entrapped signal molecule glucose is coated with redoxable manganese dioxide (MnO2) nanosheets to form the amplifiable nanoprobes (Glu-MSNs@MnO2). When encountered with PAP, the redox reaction between the MnO2 and PAP can induce the degradation of the outer layer of MSNs@MnO2, liberating multiple copies of the loaded glucose to light up the PGM signal. Owing to the high loading capability of nanocarriers, a “one-to-many” relationship exists between the target and the signal molecule glucose, which can generate adequate signal outputs to achieve the requirement of on-site determination of environmental pollutants. Taking advantage of this amplification mode, the developed PAP assay owns a dynamic linear range of 10.0–400 μM with a detection limit of 2.78 μM and provides good practical application performance with above 96.7 ± 4.83% recovery in environmental water and soil samples. Therefore, the PGM-based amplifiable sensor for PAP proposed can accommodate these requirements of environment monitoring and has promising potential for evaluating pollutants in real environmental samples. Graphical Abstract: (Figure presented.)

Original languageEnglish
Article number127
JournalMicrochimica Acta
Volume191
Issue number3
DOIs
StatePublished - Mar 2024

Keywords

  • Amplifiable nanoprobes
  • Core–shell
  • PAP, On-site detection
  • “Loading-type” nanomaterials; MnO nanosheets

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