TY - JOUR
T1 - Current advance in biological production of malic acid using wild type and metabolic engineered strains
AU - Dai, Zhongxue
AU - Zhou, Huiyuan
AU - Zhang, Shangjie
AU - Gu, Honglian
AU - Yang, Qiao
AU - Zhang, Wenming
AU - Dong, Weiliang
AU - Ma, Jiangfeng
AU - Fang, Yan
AU - Jiang, Min
AU - Xin, Fengxue
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/6
Y1 - 2018/6
N2 - Malic acid (2-hydroxybutanedioic acid) is a four-carbon dicarboxylic acid, which has attracted great interest due to its wide usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Several mature routes for malic acid production have been developed, such as chemical synthesis, enzymatic conversion and biological fermentation. With depletion of fossil fuels and concerns regarding environmental issues, biological production of malic acid has attracted more attention, which mainly consists of three pathways, namely non-oxidative pathway, oxidative pathway and glyoxylate cycle. In recent decades, metabolic engineering of model strains, and process optimization for malic acid production have been rapidly developed. Hence, this review comprehensively introduces an overview of malic acid producers and highlight some of the successful metabolic engineering approaches.
AB - Malic acid (2-hydroxybutanedioic acid) is a four-carbon dicarboxylic acid, which has attracted great interest due to its wide usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Several mature routes for malic acid production have been developed, such as chemical synthesis, enzymatic conversion and biological fermentation. With depletion of fossil fuels and concerns regarding environmental issues, biological production of malic acid has attracted more attention, which mainly consists of three pathways, namely non-oxidative pathway, oxidative pathway and glyoxylate cycle. In recent decades, metabolic engineering of model strains, and process optimization for malic acid production have been rapidly developed. Hence, this review comprehensively introduces an overview of malic acid producers and highlight some of the successful metabolic engineering approaches.
KW - Biosynthesis
KW - Carbon dioxide
KW - L-Malic acid
KW - Metabolic engineering
KW - Renewable resources
UR - http://www.scopus.com/inward/record.url?scp=85043503908&partnerID=8YFLogxK
U2 - 10.1016/j.biortech.2018.03.001
DO - 10.1016/j.biortech.2018.03.001
M3 - 文献综述
C2 - 29550171
AN - SCOPUS:85043503908
SN - 0960-8524
VL - 258
SP - 345
EP - 353
JO - Bioresource Technology
JF - Bioresource Technology
ER -
