Current advances on biological production of fumaric acid

Feng Guo; Min Wu; Zhongxue Dai; Shangjie Zhang; Wenming Zhang; Weiliang Dong; Jie Zhou; Min Jiang; Fengxue Xin

doi:10.1016/j.bej.2019.107397

Current advances on biological production of fumaric acid

Feng Guo, Min Wu, Zhongxue Dai, Shangjie Zhang, Wenming Zhang, Weiliang Dong, Jie Zhou, Min Jiang, Fengxue Xin

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Fumaric acid is an industrially important platform chemical, which has been widely used in food, chemicals, agriculture and pharmaceutical industries. Due to the rising price of raw materials in traditional petrochemical method and demand for sustainable development, fermentative fumaric acid production has attracted great attention. In this context, various strains with enhanced fumaric acid production or elimination of by-products were developed through mutagenesis or metabolic engineering. In addition, renewable organic wastes together with the fermentation process optimization have also been widely investigated. Accordingly, this review will comprehensively summarize the achievements of fermentative fumaric acid production in recent years and major obstacles occurring in industrialization to provide insights and perspective for future microbial fermentation of fumaric acid.

Original language	English
Article number	107397
Journal	Biochemical Engineering Journal
Volume	153
DOIs	https://doi.org/10.1016/j.bej.2019.107397
State	Published - 15 Jan 2020

Keywords

Fumaric acid
Process development
Strain improvement
Waste resources

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bej.2019.107397

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title = "Current advances on biological production of fumaric acid",

abstract = "Fumaric acid is an industrially important platform chemical, which has been widely used in food, chemicals, agriculture and pharmaceutical industries. Due to the rising price of raw materials in traditional petrochemical method and demand for sustainable development, fermentative fumaric acid production has attracted great attention. In this context, various strains with enhanced fumaric acid production or elimination of by-products were developed through mutagenesis or metabolic engineering. In addition, renewable organic wastes together with the fermentation process optimization have also been widely investigated. Accordingly, this review will comprehensively summarize the achievements of fermentative fumaric acid production in recent years and major obstacles occurring in industrialization to provide insights and perspective for future microbial fermentation of fumaric acid.",

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T1 - Current advances on biological production of fumaric acid

AU - Guo, Feng

AU - Wu, Min

AU - Dai, Zhongxue

AU - Zhang, Shangjie

AU - Zhang, Wenming

AU - Dong, Weiliang

AU - Zhou, Jie

AU - Jiang, Min

AU - Xin, Fengxue

PY - 2020/1/15

Y1 - 2020/1/15

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AB - Fumaric acid is an industrially important platform chemical, which has been widely used in food, chemicals, agriculture and pharmaceutical industries. Due to the rising price of raw materials in traditional petrochemical method and demand for sustainable development, fermentative fumaric acid production has attracted great attention. In this context, various strains with enhanced fumaric acid production or elimination of by-products were developed through mutagenesis or metabolic engineering. In addition, renewable organic wastes together with the fermentation process optimization have also been widely investigated. Accordingly, this review will comprehensively summarize the achievements of fermentative fumaric acid production in recent years and major obstacles occurring in industrialization to provide insights and perspective for future microbial fermentation of fumaric acid.

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KW - Process development

KW - Strain improvement

KW - Waste resources

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Current advances on biological production of fumaric acid

Abstract

Keywords

UN SDGs

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