Dehydrogenative Fluorination of gem-Difluoroalkenes to Access Multi-Substituted Trifluoromethylalkenes

Manman Wang; Mengyu Wu; Rui Ma; Kai Chen; Chuan Zhu; Chao Feng

doi:10.1002/adsc.202300491

Dehydrogenative Fluorination of gem-Difluoroalkenes to Access Multi-Substituted Trifluoromethylalkenes

Manman Wang, Mengyu Wu, Rui Ma, Kai Chen, Chuan Zhu, Chao Feng

School of Chemistry and Moleculai Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A dehydrogenative fluorination method is developed to access multi-substituted trifluoromethylalkenes starting from a variety of gem-difluoroalkenes. The reaction proceeds with electrophilic fluorination source NFSI only and accommodates a wide range of functional groups, thus complementing the previously reported protocols. Additionally, a visible-light-promoted stereoinversion is revealed to enable the access to E-isomer enriched products.

Original language	English
Pages (from-to)	2416-2421
Number of pages	6
Journal	Advanced Synthesis and Catalysis
Volume	365
Issue number	14
DOIs	https://doi.org/10.1002/adsc.202300491
State	Published - 18 Jul 2023

Keywords

Fluorination
Multi-substituents
NFSI
Trifluoromethylalkene
gem-Difluoroalkene

Access to Document

10.1002/adsc.202300491

Cite this

@article{71a2356f01b7485d832598672851b0f9,

title = "Dehydrogenative Fluorination of gem-Difluoroalkenes to Access Multi-Substituted Trifluoromethylalkenes",

abstract = "A dehydrogenative fluorination method is developed to access multi-substituted trifluoromethylalkenes starting from a variety of gem-difluoroalkenes. The reaction proceeds with electrophilic fluorination source NFSI only and accommodates a wide range of functional groups, thus complementing the previously reported protocols. Additionally, a visible-light-promoted stereoinversion is revealed to enable the access to E-isomer enriched products.",

keywords = "Fluorination, Multi-substituents, NFSI, Trifluoromethylalkene, gem-Difluoroalkene",

author = "Manman Wang and Mengyu Wu and Rui Ma and Kai Chen and Chuan Zhu and Chao Feng",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",

year = "2023",

month = jul,

day = "18",

doi = "10.1002/adsc.202300491",

language = "英语",

volume = "365",

pages = "2416--2421",

journal = "Advanced Synthesis and Catalysis",

issn = "1615-4150",

publisher = "Wiley-VCH Verlag",

number = "14",

}

TY - JOUR

T1 - Dehydrogenative Fluorination of gem-Difluoroalkenes to Access Multi-Substituted Trifluoromethylalkenes

AU - Wang, Manman

AU - Wu, Mengyu

AU - Ma, Rui

AU - Chen, Kai

AU - Zhu, Chuan

AU - Feng, Chao

PY - 2023/7/18

Y1 - 2023/7/18

N2 - A dehydrogenative fluorination method is developed to access multi-substituted trifluoromethylalkenes starting from a variety of gem-difluoroalkenes. The reaction proceeds with electrophilic fluorination source NFSI only and accommodates a wide range of functional groups, thus complementing the previously reported protocols. Additionally, a visible-light-promoted stereoinversion is revealed to enable the access to E-isomer enriched products.

AB - A dehydrogenative fluorination method is developed to access multi-substituted trifluoromethylalkenes starting from a variety of gem-difluoroalkenes. The reaction proceeds with electrophilic fluorination source NFSI only and accommodates a wide range of functional groups, thus complementing the previously reported protocols. Additionally, a visible-light-promoted stereoinversion is revealed to enable the access to E-isomer enriched products.

KW - Fluorination

KW - Multi-substituents

KW - NFSI

KW - Trifluoromethylalkene

KW - gem-Difluoroalkene

UR - http://www.scopus.com/inward/record.url?scp=85164343355&partnerID=8YFLogxK

U2 - 10.1002/adsc.202300491

DO - 10.1002/adsc.202300491

M3 - 文章

AN - SCOPUS:85164343355

SN - 1615-4150

VL - 365

SP - 2416

EP - 2421

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 14

ER -

Dehydrogenative Fluorination of gem-Difluoroalkenes to Access Multi-Substituted Trifluoromethylalkenes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this