Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone

Hui Xue Ren; You Min Sun; Dao Ji Wu; Yong Shan Ma; Han Jie Ying; Yan Ma

doi:10.1515/hc-2014-0048

Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone

Hui Xue Ren, You Min Sun, Dao Ji Wu, Yong Shan Ma, Han Jie Ying, Yan Ma

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.

Original language	English
Pages (from-to)	155-159
Number of pages	5
Journal	Heterocyclic Communications
Volume	20
Issue number	3
DOIs	https://doi.org/10.1515/hc-2014-0048
State	Published - Jun 2014

Keywords

Active phosphonate ester
Cephalosporin antibiotics
Design
Synthesis

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title = "Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone",

abstract = "For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.",

keywords = "Active phosphonate ester, Cephalosporin antibiotics, Design, Synthesis",

author = "Ren, {Hui Xue} and Sun, {You Min} and Wu, {Dao Ji} and Ma, {Yong Shan} and Ying, {Han Jie} and Yan Ma",

year = "2014",

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T1 - Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone

AU - Ren, Hui Xue

AU - Sun, You Min

AU - Wu, Dao Ji

AU - Ma, Yong Shan

AU - Ying, Han Jie

AU - Ma, Yan

PY - 2014/6

Y1 - 2014/6

N2 - For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.

AB - For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.

KW - Active phosphonate ester

KW - Cephalosporin antibiotics

KW - Design

KW - Synthesis

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DO - 10.1515/hc-2014-0048

M3 - 文章

AN - SCOPUS:84902482512

SN - 0793-0283

VL - 20

SP - 155

EP - 159

JO - Heterocyclic Communications

JF - Heterocyclic Communications

IS - 3

ER -

Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone

Abstract

Keywords

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