TY - JOUR
T1 - Determination and analysis of flutamide solubility in different solvent systems at different temperatures (T = 278.15–323.15 K)
AU - Sun, Wei
AU - Shen, Weiliang
AU - Xu, Hanhan
AU - Hu, Guoxing
AU - Deng, Zhenmei
AU - Zhao, Guoming
AU - Li, Fangzhao
AU - Hu, Yonghong
AU - Yang, Wenge
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - In this research, the solubility properties of flutamide were studied by static equilibrium method under atmospheric pressure in twelve pure solvents (acetone, methanol, tetrahydrofuran, ethyl alcohol, ethyl acetate, isopropanol, n-propanol, n-butylalcohol, isobutanol, acetonitrile, methyl acetate, 1,4-dioxane) and three mixed solvents (acetone + isopropanol, ethyl acetate + isopropanol, tetrahydrofuran + isopropanol) with the experiment temperature was set from 278.15 K to 323.15 K. The purpose of this article was studying the solubility properties of flutamide in diverse solvent systems, which can provide references for selecting good solvent and antisolvent in process of crystallize. Modified Apelblat and λh model fit the solubility data which were get from pure solvents. Their RADmax were 1.73% and 2.05%, respectively, their RMSDmax were 0.29% and 0.44%, respectively. At the same time, CNIBS/R–K and Jouyban–Acree model match the solubility data which were get from binary solvent mixtures. Their RADmax were 0.47% and 4.21%, respectively, their RMSDmax were 0.22% and 0.32%, respectively.
AB - In this research, the solubility properties of flutamide were studied by static equilibrium method under atmospheric pressure in twelve pure solvents (acetone, methanol, tetrahydrofuran, ethyl alcohol, ethyl acetate, isopropanol, n-propanol, n-butylalcohol, isobutanol, acetonitrile, methyl acetate, 1,4-dioxane) and three mixed solvents (acetone + isopropanol, ethyl acetate + isopropanol, tetrahydrofuran + isopropanol) with the experiment temperature was set from 278.15 K to 323.15 K. The purpose of this article was studying the solubility properties of flutamide in diverse solvent systems, which can provide references for selecting good solvent and antisolvent in process of crystallize. Modified Apelblat and λh model fit the solubility data which were get from pure solvents. Their RADmax were 1.73% and 2.05%, respectively, their RMSDmax were 0.29% and 0.44%, respectively. At the same time, CNIBS/R–K and Jouyban–Acree model match the solubility data which were get from binary solvent mixtures. Their RADmax were 0.47% and 4.21%, respectively, their RMSDmax were 0.22% and 0.32%, respectively.
KW - Binary solvents
KW - Flutamide
KW - KAT-LSER model
KW - Solubility
UR - http://www.scopus.com/inward/record.url?scp=85096877090&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2020.114762
DO - 10.1016/j.molliq.2020.114762
M3 - 文章
AN - SCOPUS:85096877090
SN - 0167-7322
VL - 325
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
M1 - 114762
ER -