Determination and Analysis of Solubility of 3-Bromo-2-Methylbenzoic Acid in Different Solvent Systems at Different Temperatures (T = 278.15-328.15 K)

In the present study, the solubility properties of 3-bromo-2-methyl benzoic acid were studied by the gravimetric method under atmospheric pressure. In this experiment, we chose the following eight pure solvents and three binary solvent mixtures: Tetrahydrofuran, N,N-dimethylformamide, methanol, ethyl acetate, ethanol, acetonitrile, water, cyclohexane, (water + N,N-dimethylformamide), (ethyl acetate + Tetrahydrofuran), and (acetonitrile + N,N-dimethylformamide), respectively. The experimental temperature ranged from 278.15 to 328.15 K. The solubility data of 3-bromo-2-methyl benzoic acid in different pure solvents were fitted by the modified Apelblat model and the Buchowski-Ksiazaczak λh model. For the solubility data of 3-bromo-2-methyl benzoic acid in the three groups of binary solvent mixtures, two binary solvents- solvent-fitting models (combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model and Jouyban-Acree model) and the modified Apelblat model- were used. By comparing the fitting results of each model, it could be seen that as long as the initial component was determined, the modified Apelblat model had a better correlation in both pure solvents and binary solvent mixtures. The experimental data showed that water, acetonitrile, or cyclohexane could be used as effective antisolvents of 3-bromo-2-methyl benzoic acid.