Development of polymer-encapsulated metal nanoparticles as surface-enhanced Raman scattering probes

Miaoxin Yang; Tao Chen; Wei Siang Lau; Yong Wang; Qinghu Tang; Yanhui Yang; Hongyu Chen

doi:10.1002/smll.200800777

Development of polymer-encapsulated metal nanoparticles as surface-enhanced Raman scattering probes

Miaoxin Yang, Tao Chen, Wei Siang Lau, Yong Wang, Qinghu Tang, Yanhui Yang, Hongyu Chen

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

A study was conducted to demonstrate the development of polymer-encapsulated metal nanoparticles (NP), as surface-enhanced Raman scattering (SERS) nanoprobes. The study demonstrated the encapsulation of analyte-tagged metal NPs by an amphiphilic polystyrene-block-poly(acrylic acid) diblock copolymer through self-assembly. It was demonstrated that the thermodynamically controlled process is suitable in polymer shells, having uniform thickness. It was found that these polymers were prepared, without the need for significant control, requiring a one-spot synthesis that involved simple heating and cooling. It was observed that the synthesis process is scalable and highly reproducible, giving large quantities of nanoprobes that can be isolated by direct centrifugation and resuspension in water. It was also observed that the polymer shells protect the encapsulated nanoprobes against salt-induced aggregation and oxidation by oxone (HSO₅^-.

Original language	English
Pages (from-to)	198-202
Number of pages	5
Journal	Small
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/smll.200800777
State	Published - 19 Jan 2009
Externally published	Yes

Keywords

Block copolymers
Core/shell materials
Encapsulation
Nanopartlcles
Nanoprobes

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10.1002/smll.200800777

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title = "Development of polymer-encapsulated metal nanoparticles as surface-enhanced Raman scattering probes",

abstract = "A study was conducted to demonstrate the development of polymer-encapsulated metal nanoparticles (NP), as surface-enhanced Raman scattering (SERS) nanoprobes. The study demonstrated the encapsulation of analyte-tagged metal NPs by an amphiphilic polystyrene-block-poly(acrylic acid) diblock copolymer through self-assembly. It was demonstrated that the thermodynamically controlled process is suitable in polymer shells, having uniform thickness. It was found that these polymers were prepared, without the need for significant control, requiring a one-spot synthesis that involved simple heating and cooling. It was observed that the synthesis process is scalable and highly reproducible, giving large quantities of nanoprobes that can be isolated by direct centrifugation and resuspension in water. It was also observed that the polymer shells protect the encapsulated nanoprobes against salt-induced aggregation and oxidation by oxone (HSO5-.",

keywords = "Block copolymers, Core/shell materials, Encapsulation, Nanopartlcles, Nanoprobes",

author = "Miaoxin Yang and Tao Chen and Lau, {Wei Siang} and Yong Wang and Qinghu Tang and Yanhui Yang and Hongyu Chen",

year = "2009",

month = jan,

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doi = "10.1002/smll.200800777",

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AU - Yang, Miaoxin

AU - Chen, Tao

AU - Lau, Wei Siang

AU - Wang, Yong

AU - Tang, Qinghu

AU - Yang, Yanhui

AU - Chen, Hongyu

PY - 2009/1/19

Y1 - 2009/1/19

N2 - A study was conducted to demonstrate the development of polymer-encapsulated metal nanoparticles (NP), as surface-enhanced Raman scattering (SERS) nanoprobes. The study demonstrated the encapsulation of analyte-tagged metal NPs by an amphiphilic polystyrene-block-poly(acrylic acid) diblock copolymer through self-assembly. It was demonstrated that the thermodynamically controlled process is suitable in polymer shells, having uniform thickness. It was found that these polymers were prepared, without the need for significant control, requiring a one-spot synthesis that involved simple heating and cooling. It was observed that the synthesis process is scalable and highly reproducible, giving large quantities of nanoprobes that can be isolated by direct centrifugation and resuspension in water. It was also observed that the polymer shells protect the encapsulated nanoprobes against salt-induced aggregation and oxidation by oxone (HSO5-.

AB - A study was conducted to demonstrate the development of polymer-encapsulated metal nanoparticles (NP), as surface-enhanced Raman scattering (SERS) nanoprobes. The study demonstrated the encapsulation of analyte-tagged metal NPs by an amphiphilic polystyrene-block-poly(acrylic acid) diblock copolymer through self-assembly. It was demonstrated that the thermodynamically controlled process is suitable in polymer shells, having uniform thickness. It was found that these polymers were prepared, without the need for significant control, requiring a one-spot synthesis that involved simple heating and cooling. It was observed that the synthesis process is scalable and highly reproducible, giving large quantities of nanoprobes that can be isolated by direct centrifugation and resuspension in water. It was also observed that the polymer shells protect the encapsulated nanoprobes against salt-induced aggregation and oxidation by oxone (HSO5-.

KW - Block copolymers

KW - Core/shell materials

KW - Encapsulation

KW - Nanopartlcles

KW - Nanoprobes

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JO - Small

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Development of polymer-encapsulated metal nanoparticles as surface-enhanced Raman scattering probes

Abstract

Keywords

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