Development of two-channel phosphorescent core-shell nanoprobe for ratiometric and time-resolved luminescence imaging of intracellular oxygen levels

Huibin Sun; Jie Zhang; Kenneth Yin Zhang; Shujuan Liu; Hua Liang; Wen Lv; Weili Qiao; Xiangmei Liu; Tianshe Yang; Qiang Zhao; Wei Huang

doi:10.1002/ppsc.201400106

Development of two-channel phosphorescent core-shell nanoprobe for ratiometric and time-resolved luminescence imaging of intracellular oxygen levels

Huibin Sun, Jie Zhang, Kenneth Yin Zhang, Shujuan Liu, Hua Liang, Wen Lv, Weili Qiao, Xiangmei Liu, Tianshe Yang, Qiang Zhao, Wei Huang

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

An effective strategy is developed to realize a ratiometric oxygen nanoprobe with two-channel phosphorescence signals based on a core-shell silica nanoparticle. This nanoprobe exhibits good water dispersibility and biocompatibility. Bioimaging experiments demonstrate that the nanoprobe can be used for monitoring the change in intracellular O₂ concentration and performing quantitative O₂ measurement through ratiometric and time- resolved luminescence bioimaging.

Original language	English
Pages (from-to)	48-53
Number of pages	6
Journal	Particle and Particle Systems Characterization
Volume	32
Issue number	1
DOIs	https://doi.org/10.1002/ppsc.201400106
State	Published - 1 Jan 2015

Keywords

Imaging agents
Nanoparticles
Oxygen
Phosphorescence
Sensors

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10.1002/ppsc.201400106

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Sun, H., Zhang, J., Zhang, K. Y., Liu, S., Liang, H., Lv, W., Qiao, W., Liu, X., Yang, T., Zhao, Q., & Huang, W. (2015). Development of two-channel phosphorescent core-shell nanoprobe for ratiometric and time-resolved luminescence imaging of intracellular oxygen levels. Particle and Particle Systems Characterization, 32(1), 48-53. https://doi.org/10.1002/ppsc.201400106

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title = "Development of two-channel phosphorescent core-shell nanoprobe for ratiometric and time-resolved luminescence imaging of intracellular oxygen levels",

abstract = "An effective strategy is developed to realize a ratiometric oxygen nanoprobe with two-channel phosphorescence signals based on a core-shell silica nanoparticle. This nanoprobe exhibits good water dispersibility and biocompatibility. Bioimaging experiments demonstrate that the nanoprobe can be used for monitoring the change in intracellular O2 concentration and performing quantitative O2 measurement through ratiometric and time- resolved luminescence bioimaging.",

keywords = "Imaging agents, Nanoparticles, Oxygen, Phosphorescence, Sensors",

author = "Huibin Sun and Jie Zhang and Zhang, {Kenneth Yin} and Shujuan Liu and Hua Liang and Wen Lv and Weili Qiao and Xiangmei Liu and Tianshe Yang and Qiang Zhao and Wei Huang",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH & Co. KGaA.",

year = "2015",

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doi = "10.1002/ppsc.201400106",

language = "英语",

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Sun, H, Zhang, J, Zhang, KY, Liu, S, Liang, H, Lv, W, Qiao, W, Liu, X, Yang, T, Zhao, Q & Huang, W 2015, 'Development of two-channel phosphorescent core-shell nanoprobe for ratiometric and time-resolved luminescence imaging of intracellular oxygen levels', Particle and Particle Systems Characterization, vol. 32, no. 1, pp. 48-53. https://doi.org/10.1002/ppsc.201400106

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T1 - Development of two-channel phosphorescent core-shell nanoprobe for ratiometric and time-resolved luminescence imaging of intracellular oxygen levels

AU - Sun, Huibin

AU - Zhang, Jie

AU - Zhang, Kenneth Yin

AU - Liu, Shujuan

AU - Liang, Hua

AU - Lv, Wen

AU - Qiao, Weili

AU - Liu, Xiangmei

AU - Yang, Tianshe

AU - Zhao, Qiang

AU - Huang, Wei

PY - 2015/1/1

Y1 - 2015/1/1

N2 - An effective strategy is developed to realize a ratiometric oxygen nanoprobe with two-channel phosphorescence signals based on a core-shell silica nanoparticle. This nanoprobe exhibits good water dispersibility and biocompatibility. Bioimaging experiments demonstrate that the nanoprobe can be used for monitoring the change in intracellular O2 concentration and performing quantitative O2 measurement through ratiometric and time- resolved luminescence bioimaging.

AB - An effective strategy is developed to realize a ratiometric oxygen nanoprobe with two-channel phosphorescence signals based on a core-shell silica nanoparticle. This nanoprobe exhibits good water dispersibility and biocompatibility. Bioimaging experiments demonstrate that the nanoprobe can be used for monitoring the change in intracellular O2 concentration and performing quantitative O2 measurement through ratiometric and time- resolved luminescence bioimaging.

KW - Imaging agents

KW - Nanoparticles

KW - Oxygen

KW - Phosphorescence

KW - Sensors

UR - http://www.scopus.com/inward/record.url?scp=84920930395&partnerID=8YFLogxK

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JO - Particle and Particle Systems Characterization

JF - Particle and Particle Systems Characterization

IS - 1

ER -

Development of two-channel phosphorescent core-shell nanoprobe for ratiometric and time-resolved luminescence imaging of intracellular oxygen levels

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Keywords

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