Double network hydrogel for tissue engineering

Zhipeng Gu, Keqing Huang, Yan Luo, Laibao Zhang, Tairong Kuang, Zhou Chen, Guochao Liao

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations

Abstract

Double network (DN) hydrogels, a kind of promising soft and tough hydrogels, are produced by two unique contrasting networks with designed network entanglement burst into the field of materials science as versatile functional systems for a very broad range of applications. A part of the DN hydrogels is characterized by extraordinary mechanical properties providing efficient biocompatible and high strength for holding considerable promise in tissue engineering. Following DN hydrogels principles and consideration of biomedical applications, we provide an overall view of the present various DN hydrogels and look forward to the future of DN hydrogels for tissue engineering. In this review, the preparation methods, structure, properties, current situation, and challenges are mainly discussed for the purpose of tissue engineering. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement.

Original languageEnglish
Article numbere1520
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume10
Issue number6
DOIs
StatePublished - 1 Nov 2018

Keywords

  • bone construction
  • cartilage repair
  • double network
  • hydrogels
  • tissue engineering

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