Efficient astaxanthin production: Advanced strategies to improve microbial fermentation

Qiang Zhou; Jiahui Yang; Wankui Jiang; Wenming Zhang; Minjiao Chen; Yujia Jiang; Fengxue Xin

doi:10.1002/bbb.2709

Efficient astaxanthin production: Advanced strategies to improve microbial fermentation

Qiang Zhou, Jiahui Yang, Wankui Jiang, Wenming Zhang, Minjiao Chen, Yujia Jiang, Fengxue Xin

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Astaxanthin is a very valuable chemical with strong antioxidant effects, including anti-cancer, anti-inflammatory, eye protection, and other properties. The rapid development of synthetic biology has facilitated microbial astaxanthin production, offering environmental benefits, mild reaction conditions, and alignment with consumer demand for natural compounds. Accordingly, this review introduces the latest progress in the production of astaxanthin using different microorganisms including native microbes like Haematococcus pluvialis and Xanthophyllomyces dendrorhous, as well as engineered microbes like Yarrowia lipolytica and Escherichia coli. Methods for improving astaxanthin production through fermentation process regulation and metabolic engineering are reviewed and directions for future work are proposed.

Original language	English
Pages (from-to)	469-484
Number of pages	16
Journal	Biofuels, Bioproducts and Biorefining
Volume	19
Issue number	2
DOIs	https://doi.org/10.1002/bbb.2709
State	Published - 1 Mar 2025

Keywords

astaxanthin
biosynthesis
fermentation
microorganisms
terpenoids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/bbb.2709

Cite this

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title = "Efficient astaxanthin production: Advanced strategies to improve microbial fermentation",

abstract = "Astaxanthin is a very valuable chemical with strong antioxidant effects, including anti-cancer, anti-inflammatory, eye protection, and other properties. The rapid development of synthetic biology has facilitated microbial astaxanthin production, offering environmental benefits, mild reaction conditions, and alignment with consumer demand for natural compounds. Accordingly, this review introduces the latest progress in the production of astaxanthin using different microorganisms including native microbes like Haematococcus pluvialis and Xanthophyllomyces dendrorhous, as well as engineered microbes like Yarrowia lipolytica and Escherichia coli. Methods for improving astaxanthin production through fermentation process regulation and metabolic engineering are reviewed and directions for future work are proposed.",

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TY - JOUR

T1 - Efficient astaxanthin production

T2 - Advanced strategies to improve microbial fermentation

AU - Zhou, Qiang

AU - Yang, Jiahui

AU - Jiang, Wankui

AU - Zhang, Wenming

AU - Chen, Minjiao

AU - Jiang, Yujia

AU - Xin, Fengxue

PY - 2025/3/1

Y1 - 2025/3/1

N2 - Astaxanthin is a very valuable chemical with strong antioxidant effects, including anti-cancer, anti-inflammatory, eye protection, and other properties. The rapid development of synthetic biology has facilitated microbial astaxanthin production, offering environmental benefits, mild reaction conditions, and alignment with consumer demand for natural compounds. Accordingly, this review introduces the latest progress in the production of astaxanthin using different microorganisms including native microbes like Haematococcus pluvialis and Xanthophyllomyces dendrorhous, as well as engineered microbes like Yarrowia lipolytica and Escherichia coli. Methods for improving astaxanthin production through fermentation process regulation and metabolic engineering are reviewed and directions for future work are proposed.

AB - Astaxanthin is a very valuable chemical with strong antioxidant effects, including anti-cancer, anti-inflammatory, eye protection, and other properties. The rapid development of synthetic biology has facilitated microbial astaxanthin production, offering environmental benefits, mild reaction conditions, and alignment with consumer demand for natural compounds. Accordingly, this review introduces the latest progress in the production of astaxanthin using different microorganisms including native microbes like Haematococcus pluvialis and Xanthophyllomyces dendrorhous, as well as engineered microbes like Yarrowia lipolytica and Escherichia coli. Methods for improving astaxanthin production through fermentation process regulation and metabolic engineering are reviewed and directions for future work are proposed.

KW - astaxanthin

KW - biosynthesis

KW - fermentation

KW - microorganisms

KW - terpenoids

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M3 - 文献综述

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VL - 19

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JO - Biofuels, Bioproducts and Biorefining

JF - Biofuels, Bioproducts and Biorefining

IS - 2

ER -

Efficient astaxanthin production: Advanced strategies to improve microbial fermentation

Abstract

Keywords

UN SDGs

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