Electrochemical Oxidative [3 + 2] Annulation of p-Methoxy Anilines with Enaminones toward 3-Acyl Indoles

Luchao Li; Pei Guan; Yongfang Wang; Longyu Deng; Caipeng Wang; Delong Ma; Yan Meng; Zheng Fang; Jindian Duan; Kai Guo

doi:10.1002/adsc.9597

Electrochemical Oxidative [3 + 2] Annulation of p-Methoxy Anilines with Enaminones toward 3-Acyl Indoles

Luchao Li, Pei Guan, Yongfang Wang, Longyu Deng, Caipeng Wang, Delong Ma, Yan Meng, Zheng Fang, Jindian Duan, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

Abstract

An electrochemical oxidative [3 + 2] annulation of p-methoxy anilines with enaminones is reported. This protocol enables facile synthesis of 3-acyl indoles in moderate to good yields under mild conditions, featuring excellent functional group tolerance, operational simplicity, and gram-scale scalability. Based on the cyclic voltammetry and control experiments, a plausible mechanism involving the aniline radical pathway is proposed.

Original language	English
Journal	Advanced Synthesis and Catalysis
DOIs	https://doi.org/10.1002/adsc.9597
State	Accepted/In press - 2025

Keywords

anilines
annulation
electrosynthesis
enaminones
indoles

Access to Document

10.1002/adsc.9597

Cite this

@article{e39bb9e5d5de40ca8ed5b06656fc4065,

title = "Electrochemical Oxidative [3 + 2] Annulation of p-Methoxy Anilines with Enaminones toward 3-Acyl Indoles",

abstract = "An electrochemical oxidative [3 + 2] annulation of p-methoxy anilines with enaminones is reported. This protocol enables facile synthesis of 3-acyl indoles in moderate to good yields under mild conditions, featuring excellent functional group tolerance, operational simplicity, and gram-scale scalability. Based on the cyclic voltammetry and control experiments, a plausible mechanism involving the aniline radical pathway is proposed.",

keywords = "anilines, annulation, electrosynthesis, enaminones, indoles",

author = "Luchao Li and Pei Guan and Yongfang Wang and Longyu Deng and Caipeng Wang and Delong Ma and Yan Meng and Zheng Fang and Jindian Duan and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2025 Wiley-VCH GmbH.",

year = "2025",

doi = "10.1002/adsc.9597",

language = "英语",

journal = "Advanced Synthesis and Catalysis",

issn = "1615-4150",

publisher = "Wiley-VCH Verlag",

}

TY - JOUR

T1 - Electrochemical Oxidative [3 + 2] Annulation of p-Methoxy Anilines with Enaminones toward 3-Acyl Indoles

AU - Li, Luchao

AU - Guan, Pei

AU - Wang, Yongfang

AU - Deng, Longyu

AU - Wang, Caipeng

AU - Ma, Delong

AU - Meng, Yan

AU - Fang, Zheng

AU - Duan, Jindian

AU - Guo, Kai

PY - 2025

Y1 - 2025

N2 - An electrochemical oxidative [3 + 2] annulation of p-methoxy anilines with enaminones is reported. This protocol enables facile synthesis of 3-acyl indoles in moderate to good yields under mild conditions, featuring excellent functional group tolerance, operational simplicity, and gram-scale scalability. Based on the cyclic voltammetry and control experiments, a plausible mechanism involving the aniline radical pathway is proposed.

AB - An electrochemical oxidative [3 + 2] annulation of p-methoxy anilines with enaminones is reported. This protocol enables facile synthesis of 3-acyl indoles in moderate to good yields under mild conditions, featuring excellent functional group tolerance, operational simplicity, and gram-scale scalability. Based on the cyclic voltammetry and control experiments, a plausible mechanism involving the aniline radical pathway is proposed.

KW - anilines

KW - annulation

KW - electrosynthesis

KW - enaminones

KW - indoles

UR - http://www.scopus.com/inward/record.url?scp=105007903859&partnerID=8YFLogxK

U2 - 10.1002/adsc.9597

DO - 10.1002/adsc.9597

M3 - 文章

AN - SCOPUS:105007903859

SN - 1615-4150

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

ER -

Electrochemical Oxidative [3 + 2] Annulation of p-Methoxy Anilines with Enaminones toward 3-Acyl Indoles

Abstract

Keywords

Access to Document

Other files and links

Cite this