Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

Yajie Fu; Zeping Lu; Ke Fang; Xinyi He; Huajin Xu; Yi Hu

doi:10.1039/c9ra10014h

Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

Yajie Fu, Zeping Lu, Ke Fang, Xinyi He, Huajin Xu, Yi Hu

School of Pharmaceutical Sciences

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.

Original language	English
Pages (from-to)	10848-10853
Number of pages	6
Journal	RSC Advances
Volume	10
Issue number	18
DOIs	https://doi.org/10.1039/c9ra10014h
State	Published - 16 Mar 2020

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abstract = "A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.",

author = "Yajie Fu and Zeping Lu and Ke Fang and Xinyi He and Huajin Xu and Yi Hu",

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AU - Fu, Yajie

AU - Lu, Zeping

AU - Fang, Ke

AU - He, Xinyi

AU - Xu, Huajin

AU - Hu, Yi

PY - 2020/3/16

Y1 - 2020/3/16

N2 - A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.

AB - A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.

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M3 - 文章

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SP - 10848

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JO - RSC Advances

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ER -

Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

Abstract

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