TY - JOUR
T1 - Experimental measurement and thermodynamic models for solid-liquid equilibrium of hyodeoxycholic acid in different organic solvents
AU - Yang, Yang
AU - Hu, Yonghong
AU - Zhang, Qi
AU - Cheng, Limin
AU - Cao, Cuicui
AU - Yang, Wenge
AU - Shen, Fei
N1 - Publisher Copyright:
© 2014 Published by Elsevier B.V.
PY - 2015/2
Y1 - 2015/2
N2 - Data on corresponding solid-liquid equilibrium of hyodeoxycholic acid (HDCA) in different solvents is essential for a preliminary study of industrial applications. In this paper, the solid-liquid equilibriumof HDCA in methanol, ethanol, isopropyl alcohol, butan-1-ol, ethyl acetate, acetone, acetonitrile, and acetic acid was explored at temperatures ranging from 278.15 to 333.15 K under atmosphere pressure. For the temperature range investigated, the solubility of HDCA in the solvents increased with increasing temperature. The modified Apelblat model, the Buchowski-Ksiazaczak λh model, and ideal modelwere adopted to describe and predict the change tendency of solubility. Besides, the calculated thermodynamic parameters indicated that in each studied solvent the dissolution process of HDCA is endothermic. Based on the analysis above, ethanol is considered to be the best solvent in crystallization process of HDCA.
AB - Data on corresponding solid-liquid equilibrium of hyodeoxycholic acid (HDCA) in different solvents is essential for a preliminary study of industrial applications. In this paper, the solid-liquid equilibriumof HDCA in methanol, ethanol, isopropyl alcohol, butan-1-ol, ethyl acetate, acetone, acetonitrile, and acetic acid was explored at temperatures ranging from 278.15 to 333.15 K under atmosphere pressure. For the temperature range investigated, the solubility of HDCA in the solvents increased with increasing temperature. The modified Apelblat model, the Buchowski-Ksiazaczak λh model, and ideal modelwere adopted to describe and predict the change tendency of solubility. Besides, the calculated thermodynamic parameters indicated that in each studied solvent the dissolution process of HDCA is endothermic. Based on the analysis above, ethanol is considered to be the best solvent in crystallization process of HDCA.
KW - Apelblat model
KW - Hyodeoxycholic acid
KW - Ideal model
KW - Thermodynamic parameters
KW - λH model
UR - http://www.scopus.com/inward/record.url?scp=84917673283&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2014.12.007
DO - 10.1016/j.molliq.2014.12.007
M3 - 文章
AN - SCOPUS:84917673283
SN - 0167-7322
VL - 202
SP - 17
EP - 22
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
ER -