Facile and efficient synthesis of a new class of indole-substituted pyridine derivatives via one-pot multicomponent reactions

Kai Zhao; Xiao Ping Xu; Song Lei Zhu; Da Qing Shi; Yong Zhang; Shun Jun Ji

doi:10.1055/s-0029-1216873

Facile and efficient synthesis of a new class of indole-substituted pyridine derivatives via one-pot multicomponent reactions

Kai Zhao, Xiao Ping Xu, Song Lei Zhu, Da Qing Shi, Yong Zhang, Shun Jun Ji

Soochow University

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A new series of indole-containing pyridine derivatives, 4-aryl-6-(1H-indol-3-yl)-2,2¢-bipyridine-5-carbonitriles, were synthesized via one-pot multicomponent reactions of 3-(cyanoacetyl) indoles, aldehydes, heterocyclic ketones, and ammonium acetate. Particularly valuable features of this method include high yields of products, broad substrate scope, and straightforward procedures.

Original language	English
Pages (from-to)	2697-2708
Number of pages	12
Journal	Synthesis (Germany)
Issue number	16
DOIs	https://doi.org/10.1055/s-0029-1216873
State	Published - 2009
Externally published	Yes

Keywords

Heterocycles
Indole
Multicomponent reactions
One-pot synthesis
Pyridine derivatives

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10.1055/s-0029-1216873

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title = "Facile and efficient synthesis of a new class of indole-substituted pyridine derivatives via one-pot multicomponent reactions",

abstract = "A new series of indole-containing pyridine derivatives, 4-aryl-6-(1H-indol-3-yl)-2,2¢-bipyridine-5-carbonitriles, were synthesized via one-pot multicomponent reactions of 3-(cyanoacetyl) indoles, aldehydes, heterocyclic ketones, and ammonium acetate. Particularly valuable features of this method include high yields of products, broad substrate scope, and straightforward procedures.",

keywords = "Heterocycles, Indole, Multicomponent reactions, One-pot synthesis, Pyridine derivatives",

author = "Kai Zhao and Xu, {Xiao Ping} and Zhu, {Song Lei} and Shi, {Da Qing} and Yong Zhang and Ji, {Shun Jun}",

year = "2009",

doi = "10.1055/s-0029-1216873",

language = "英语",

pages = "2697--2708",

journal = "Synthesis (Germany)",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - Facile and efficient synthesis of a new class of indole-substituted pyridine derivatives via one-pot multicomponent reactions

AU - Zhao, Kai

AU - Xu, Xiao Ping

AU - Zhu, Song Lei

AU - Shi, Da Qing

AU - Zhang, Yong

AU - Ji, Shun Jun

PY - 2009

Y1 - 2009

N2 - A new series of indole-containing pyridine derivatives, 4-aryl-6-(1H-indol-3-yl)-2,2¢-bipyridine-5-carbonitriles, were synthesized via one-pot multicomponent reactions of 3-(cyanoacetyl) indoles, aldehydes, heterocyclic ketones, and ammonium acetate. Particularly valuable features of this method include high yields of products, broad substrate scope, and straightforward procedures.

AB - A new series of indole-containing pyridine derivatives, 4-aryl-6-(1H-indol-3-yl)-2,2¢-bipyridine-5-carbonitriles, were synthesized via one-pot multicomponent reactions of 3-(cyanoacetyl) indoles, aldehydes, heterocyclic ketones, and ammonium acetate. Particularly valuable features of this method include high yields of products, broad substrate scope, and straightforward procedures.

KW - Heterocycles

KW - Indole

KW - Multicomponent reactions

KW - One-pot synthesis

KW - Pyridine derivatives

UR - http://www.scopus.com/inward/record.url?scp=70449411269&partnerID=8YFLogxK

U2 - 10.1055/s-0029-1216873

DO - 10.1055/s-0029-1216873

M3 - 文章

AN - SCOPUS:70449411269

SN - 0039-7881

SP - 2697

EP - 2708

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 16

ER -

Facile and efficient synthesis of a new class of indole-substituted pyridine derivatives via one-pot multicomponent reactions

Abstract

Keywords

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