TY - JOUR
T1 - Facile synthesis of self-healing gels via frontal polymerization toward acid–base regulatable wound dressing
AU - He, Zi Liang
AU - Liu, Ji Dong
AU - Hu, Jie
AU - Wang, Cai Feng
AU - Li, Qing
AU - Wang, Gefei
AU - Chen, Su
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/7
Y1 - 2022/7
N2 - Advanced pH-regulated wound dressing that can promote wound healing remains a key challenge. To this end, we herein report a self-healing assembly strategy toward pH-regulated gel wound dressing. Firstly, we synthesized acrylic acid (AA)-based Gel 1 by a facile frontal polymerization (FP), which is rich in carboxy groups, endowing the gel with excellent self-healing and pH sensitivity. Then we constructed carboxymethyl chitosan and acrylamide (CMCS-AM)-based Gel 2, which shows reverse pH sensitivity against Gel 1. Thus, the Gel 1/Gel 2 bilayer exhibits different bending behaviors based on the reverse pH sensitivity, providing opportunities for pH regulation. More importantly, the in vivo study indicates that the Gel 1/Gel 2 assembly can effectively adjust the pH microenvironment, which consists of the non-infected wound pH change (from alkalinity to acidity and back again). The Gel 1 can continuously dissociate H+ to the wound, while the Gel 2 can adopt these ions, which synergistically realize the pH regulation based on the dissociation–adsorption rates difference and then accelerate the wound healing. This work offers a facile way to construct self-healing gels by FP, as well as a self-healing assembly strategy for advanced wound dressing with pH regulation, which is of great significance in wound healing area. Graphical abstract: [Figure not available: see fulltext.]
AB - Advanced pH-regulated wound dressing that can promote wound healing remains a key challenge. To this end, we herein report a self-healing assembly strategy toward pH-regulated gel wound dressing. Firstly, we synthesized acrylic acid (AA)-based Gel 1 by a facile frontal polymerization (FP), which is rich in carboxy groups, endowing the gel with excellent self-healing and pH sensitivity. Then we constructed carboxymethyl chitosan and acrylamide (CMCS-AM)-based Gel 2, which shows reverse pH sensitivity against Gel 1. Thus, the Gel 1/Gel 2 bilayer exhibits different bending behaviors based on the reverse pH sensitivity, providing opportunities for pH regulation. More importantly, the in vivo study indicates that the Gel 1/Gel 2 assembly can effectively adjust the pH microenvironment, which consists of the non-infected wound pH change (from alkalinity to acidity and back again). The Gel 1 can continuously dissociate H+ to the wound, while the Gel 2 can adopt these ions, which synergistically realize the pH regulation based on the dissociation–adsorption rates difference and then accelerate the wound healing. This work offers a facile way to construct self-healing gels by FP, as well as a self-healing assembly strategy for advanced wound dressing with pH regulation, which is of great significance in wound healing area. Graphical abstract: [Figure not available: see fulltext.]
UR - http://www.scopus.com/inward/record.url?scp=85133452028&partnerID=8YFLogxK
U2 - 10.1007/s10853-022-07403-5
DO - 10.1007/s10853-022-07403-5
M3 - 文章
AN - SCOPUS:85133452028
SN - 0022-2461
VL - 57
SP - 12971
EP - 12984
JO - Journal of Materials Science
JF - Journal of Materials Science
IS - 27
ER -