Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications

Chunhui Dai; Dongliang Yang; Wenjie Zhang; Biqing Bao; Yixiang Cheng; Lianhui Wang

doi:10.1039/c5py00344j

Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications

Chunhui Dai, Dongliang Yang, Wenjie Zhang, Biqing Bao, Yixiang Cheng, Lianhui Wang

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A novel chiral conjugated polymer is developed and used for the preparation of conjugated polymer nanoparticles (CPNs) with particle sizes ranging from 80 to 190 nm. The size-dependent optical properties of chiral CPNs are fully studied and it was found that the nanoparticles exhibited a prominent red shift both in UV-vis and fluorescence emission with increasing diameters. The circular dichroism (CD) spectra and anisotropy r values of the CPNs display size-tunable chirality features, which can be attributed to the nature of the aggregates as nanoparticles grow. Meanwhile, the obtained CPNs can serve as efficient far-red/near-infrared (FR/NIR) fluorescent probes with low cytotoxicity and high photostability for HeLa cell imaging.

Original language	English
Pages (from-to)	3962-3969
Number of pages	8
Journal	Polymer Chemistry
Volume	6
Issue number	21
DOIs	https://doi.org/10.1039/c5py00344j
State	Published - 7 Jun 2015
Externally published	Yes

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title = "Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications",

abstract = "A novel chiral conjugated polymer is developed and used for the preparation of conjugated polymer nanoparticles (CPNs) with particle sizes ranging from 80 to 190 nm. The size-dependent optical properties of chiral CPNs are fully studied and it was found that the nanoparticles exhibited a prominent red shift both in UV-vis and fluorescence emission with increasing diameters. The circular dichroism (CD) spectra and anisotropy r values of the CPNs display size-tunable chirality features, which can be attributed to the nature of the aggregates as nanoparticles grow. Meanwhile, the obtained CPNs can serve as efficient far-red/near-infrared (FR/NIR) fluorescent probes with low cytotoxicity and high photostability for HeLa cell imaging.",

author = "Chunhui Dai and Dongliang Yang and Wenjie Zhang and Biqing Bao and Yixiang Cheng and Lianhui Wang",

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T1 - Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications

AU - Dai, Chunhui

AU - Yang, Dongliang

AU - Zhang, Wenjie

AU - Bao, Biqing

AU - Cheng, Yixiang

AU - Wang, Lianhui

PY - 2015/6/7

Y1 - 2015/6/7

N2 - A novel chiral conjugated polymer is developed and used for the preparation of conjugated polymer nanoparticles (CPNs) with particle sizes ranging from 80 to 190 nm. The size-dependent optical properties of chiral CPNs are fully studied and it was found that the nanoparticles exhibited a prominent red shift both in UV-vis and fluorescence emission with increasing diameters. The circular dichroism (CD) spectra and anisotropy r values of the CPNs display size-tunable chirality features, which can be attributed to the nature of the aggregates as nanoparticles grow. Meanwhile, the obtained CPNs can serve as efficient far-red/near-infrared (FR/NIR) fluorescent probes with low cytotoxicity and high photostability for HeLa cell imaging.

AB - A novel chiral conjugated polymer is developed and used for the preparation of conjugated polymer nanoparticles (CPNs) with particle sizes ranging from 80 to 190 nm. The size-dependent optical properties of chiral CPNs are fully studied and it was found that the nanoparticles exhibited a prominent red shift both in UV-vis and fluorescence emission with increasing diameters. The circular dichroism (CD) spectra and anisotropy r values of the CPNs display size-tunable chirality features, which can be attributed to the nature of the aggregates as nanoparticles grow. Meanwhile, the obtained CPNs can serve as efficient far-red/near-infrared (FR/NIR) fluorescent probes with low cytotoxicity and high photostability for HeLa cell imaging.

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Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications

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